SCN3B Gene Summary [Human]

Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit and one or more regulatory beta subunits. They are responsible for the generation and propagation of action potentials in neurons and muscle. This gene encodes one member of the sodium channel beta subunit gene family, and influences the inactivation kinetics of the sodium channel. Two alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]

Details

Type
Retained Intron
Official Symbol
SCN3B
Official Name
sodium voltage-gated channel beta subunit 3 [Source:HGNC Symbol;Acc:HGNC:20665]
Ensembl ID
ENSG00000166257
Bio databases IDs NCBI: 55800 Ensembl: ENSG00000166257
Aliases sodium voltage-gated channel beta subunit 3
Synonyms 1110001K16Rik, 4833414B02Rik, ATFB16, BRGDA7, HSA243396, KIAA1158, SCNB3, sodium channel, voltage-gated, type III, beta, sodium channel, voltage-gated, type III, β, sodium voltage-gated channel beta subunit 3, sodium voltage-gated channel β subunit 3
Species
Human, Homo sapiens
OrthologiesMouseRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SCN3B often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • voltage-gated sodium channel
  • Immunoglobulin V-Type
  • immunoglobulin domain
  • Immunoglobulin like
  • ion channel binding
  • sodium channel regulator
  • protein binding
  • ion channel
  • Immunoglobulin V-set domain

Pathways

Biological processes and signaling networks where the SCN3B gene in human plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • colorectal cancer
  • migraines
  • epilepsy
  • weight gain
  • amyotrophic lateral sclerosis
  • localization-related epilepsy
  • schizophrenia
  • Huntington disease
  • obesity
  • familial atrial fibrillation
regulates
role in cell
  • apoptosis
  • colony formation
  • depolarization

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Plasma Membrane
  • intracellular membrane-bounded organelle
  • Cytoplasm
  • cellular membrane
  • Endoplasmic Reticulum
  • cytosol
  • Z line
  • membrane rafts

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the human SCN3B gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • regulation of cardiac muscle cell action potential involved in contraction
  • positive regulation of heart rate
  • regulation of atrial cardiac muscle cell action potential
  • membrane depolarization involved in regulation of cardiac muscle cell action potential
  • regulation of atrial cardiomyocyte membrane depolarization
  • regulation of SA node cardiac muscle cell action potential
  • regulation of ventricular cardiac muscle cell action potential
  • regulation of ventricular cardiomyocyte membrane depolarization
  • nervous system development
  • cardiac muscle contraction
  • sodium ion transport
  • regulation of sodium ion transmembrane transporter activity
  • positive regulation of sodium ion transport
  • sodium ion transmembrane transport
  • regulation of heart rate by cardiac conduction
  • membrane depolarization
  • membrane depolarization involved in regulation of action potential
  • protein localization in plasma membrane

Cellular Component

Where in the cell the gene product is active
  • Z disc
  • membrane
  • voltage-gated sodium channel complex
  • plasma membrane

Molecular Function

What the gene product does at the molecular level
  • sodium channel regulator activity
  • protein binding
  • voltage-gated sodium channel activity involved in regulation of cardiac muscle cell action potential
  • sodium channel inhibitor activity
  • ion channel binding

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.