RRP8 Gene Summary [Human]
Enables methylated histone binding activity. Involved in several processes, including cellular response to glucose starvation; intrinsic apoptotic signaling pathway by p53 class mediator; and regulation of gene expression. Located in several cellular components, including cytosol; nuclear lumen; and rDNA heterochromatin. Part of chromatin silencing complex. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | RRP8 |
| Official Name | ribosomal RNA processing 8 [Source:HGNC Symbol;Acc:HGNC:29030] |
| Ensembl ID | ENSG00000132275 |
| Bio databases IDs | |
| Aliases | ribosomal RNA processing 8, RRP8 methyltransferase homolog (S. cerevisiae), nucleomethylin |
| Synonyms | 1500003O22Rik, 2900001K19Rik, KIAA0409, NML, RGD1308302, ribosomal RNA processing 8 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human RRP8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- histone binding
- protein binding activity, bridging
- enzyme
- protein binding
- AdoMet_MTases
- methyltransferase domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- heterochromatin
- Plasma Membrane
- cytosol
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human RRP8 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription, DNA-dependent
- chromatin silencing at rDNA
- signal transduction by p53 class mediator resulting in induction of apoptosis
- energy homeostasis
- negative regulation of cell cycle
- regulation of transcription by glucose
- rRNA processing
- cellular response to glucose starvation
- methylation
Cellular Component
Where in the cell the gene product is active
- cytosol
- rDNA heterochromatin
- nucleolus
- chromatin silencing complex
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA binding
- methylated histone residue binding
- S-adenosylmethionine-dependent methyltransferase activity