WBP4 Gene Summary [Human]
This gene encodes WW domain-containing binding protein 4. The WW domain represents a small and compact globular structure that interacts with proline-rich ligands. This encoded protein is a general spliceosomal protein that may play a role in cross-intron bridging of U1 and U2 snRNPs in the spliceosomal complex A. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | WBP4 |
| Official Name | WW domain binding protein 4 [Source:HGNC Symbol;Acc:HGNC:12739] |
| Ensembl ID | ENSG00000120688 |
| Bio databases IDs | |
| Aliases | WW domain binding protein 4, formin binding protein 21 |
| Synonyms | BB101031, FBP21, formin binding protein 21, NEDHFDB, WW domain binding protein 4 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human WBP4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Domain with 2 conserved Trp (W) residues
- WW
- U1 zinc finger
- protein binding
- proline rich domain
- WW domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- nuclear fraction
- Nucleus
- spliceosomes
- nucleoplasm
- nuclear speckles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human WBP4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- nuclear mRNA cis splicing, via spliceosome
- RNA splicing
- nuclear mRNA splicing, via spliceosome
Cellular Component
Where in the cell the gene product is active
- nucleus
- precatalytic spliceosome
- nuclear speck
- U2-type precatalytic spliceosome
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- proline-rich region binding
- zinc ion binding
- protein binding
- RNA binding