PABPC1 Gene Summary [Human]
This gene encodes a poly(A) binding protein. The protein shuttles between the nucleus and cytoplasm and binds to the 3' poly(A) tail of eukaryotic messenger RNAs via RNA-recognition motifs. The binding of this protein to poly(A) promotes ribosome recruitment and translation initiation; it is also required for poly(A) shortening which is the first step in mRNA decay. The gene is part of a small gene family including three protein-coding genes and several pseudogenes.[provided by RefSeq, Aug 2010]
Details
| Type | Protein Coding |
| Official Symbol | PABPC1 |
| Official Name | poly(A) binding protein cytoplasmic 1 [Source:HGNC Symbol;Acc:HGNC:8554] |
| Ensembl ID | ENSG00000070756 |
| Bio databases IDs | |
| Aliases | poly(A) binding protein cytoplasmic 1 |
| Synonyms | ePAB, PAB1, PABP, PABP 1, PABPC2, PabpI, PABPL1, POLYA binding, poly(A) binding protein cytoplasmic 1, poly(A) binding protein, cytoplasmic 1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PABPC1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ELAV/HuD family splicing factor
- RNA recognition motif (RRM) superfamily
- RNA recognition motif
- mRNA binding
- translation activator
- poly(A) binding protein
- protein binding
- zDHHC ankyrin repeat binding domain
- heterogeneous nuclear ribonucleoprotein R, Q family
- Poly-adenylate binding protein, unique domain
- C-terminal domain of Poly(A)-binding protein
- translation regulator
- RNA binding
- poly(U) binding protein
- polyadenylate binding protein, human types 1, 2, 3, 4 family
- mRNA 3' UTR binding
- poly-U binding splicing factor, half-pint family
Pathways
Biological processes and signaling networks where the PABPC1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- hepatocellular carcinoma
- metastasis
- rectum cancer
- COVID-19
- organismal death
- acute myeloid leukemia
- renal clear cell adenocarcinoma
- diffuse large B-cell lymphoma
- epithelial neoplasia
role in cell
- quantity
- expression in
- apoptosis
- cell viability
- phosphorylation in
- cell death
- accumulation in
- migration
- transformation
- survival
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- polyribosome fractions
- detergent resistant lipid raft fraction
- catalytic step 2 spliceosome
- cytoplasmic ribonucleoprotein granule
- cellular membrane
- ribosome
- Nucleus
- cytosol
- spliceosomes
- synapse
- stress granule
- cell membrane leading edge
- perikaryon
- dendrites
- paraspeckle-like structures
- cytoplasmic fraction
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PABPC1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of cytoplasmic translation
- nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
- positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
- negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
- mRNA stabilization
- gene silencing by RNA
- negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
- positive regulation of viral genome replication
- positive regulation of nuclear-transcribed mRNA poly(A) tail shortening
- CRD-mediated mRNA stabilization
- nuclear mRNA splicing, via spliceosome
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasmic stress granule
- extracellular vesicular exosome
- catalytic step 2 spliceosome
- focal adhesion
- cytoplasm
- cell leading edge
- membrane
- cytosol
- lamellipodium
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA binding
- poly(A) RNA binding
- translation activator activity
- mRNA binding
- poly(U) RNA binding
- mRNA 3'-UTR binding