CPSF6 Gene Summary [Human]
The protein encoded by this gene is one subunit of a cleavage factor required for 3' RNA cleavage and polyadenylation processing. The interaction of the protein with the RNA is one of the earliest steps in the assembly of the 3' end processing complex and facilitates the recruitment of other processing factors. The cleavage factor complex is composed of four polypeptides. This gene encodes the 68kD subunit. It has a domain organization reminiscent of spliceosomal proteins. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | CPSF6 |
| Official Name | cleavage and polyadenylation specific factor 6 [Source:HGNC Symbol;Acc:HGNC:13871] |
| Ensembl ID | ENSG00000111605 |
| Bio databases IDs | |
| Aliases | cleavage and polyadenylation specific factor 6, cleavage factor Im complex 68 kDa subunit |
| Synonyms | 4733401N12RIK, CFIM, CFIM68, CFIM72, cleavage and polyadenylation specific factor 6, HPBRII-4, HPBRII-7, Pre-mRNA cleavage factor im, SPSF6 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CPSF6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA recognition motif (RRM) superfamily
- binding protein
- RNA recognition motif
- mRNA binding
- protein binding
- ribosomal large subunit binding
- RNA binding
Pathways
Biological processes and signaling networks where the CPSF6 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- osteoarthritis
- infection by HIV-1
- pain
- castration refractory prostate cancer
- metabolic syndrome X
- peripheral arterial disease
role in cell
- expression in
- phosphorylation in
- reactivation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- perichromatin fibril
- interchromatin granule-associated zone
- perichromatin granule
- nuclear chromatin
- Cytoplasm
- spliceosomes
- nuclear foci
- interchromatin granules
- nucleoplasm
- nuclear bodies
- interchromatin granule clusters
- nuclear speckles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CPSF6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein tetramerization
- mRNA 3'-end processing
- mRNA processing
- protein heterotetramerization
- positive regulation of RNA export from nucleus
Cellular Component
Where in the cell the gene product is active
- nucleus
- mRNA cleavage and polyadenylation specificity factor complex
- cytoplasm
- paraspeckles
- perichromatin fibrils
- nuclear speck
- membrane
- mRNA cleavage factor complex
- interchromatin granule
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA binding
- mRNA binding
- ribosomal large subunit binding