ADRA1A Gene Summary [Human]
Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. This gene encodes alpha-1A-adrenergic receptor. Alternative splicing of this gene generates four transcript variants, which encode four different isoforms with distinct C-termini but having similar ligand binding properties. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | ADRA1A |
| Official Name | adrenoceptor alpha 1A [Source:HGNC Symbol;Acc:HGNC:277] |
| Ensembl ID | ENSG00000120907 |
| Bio databases IDs | |
| Aliases | adrenoceptor alpha 1A |
| Synonyms | ADRA1C, ADRA1L1, Adrenergic Receptor alpha1a, adrenergic receptor, alpha 1a, adrenergic receptor, α 1a, adrenoceptor alpha 1A, adrenoceptor α 1A, Alpha1a adrenoceptor, Alpha1a adrenoreceptor, ALPHA1AAR, α 1a adrenergic receptor, α-1a AR |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ADRA1A often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- Cholecystokinin A receptor, N-terminal
- transmembrane domain
- 7 transmembrane receptor (rhodopsin family)
- tail domain
- protein binding
- seven-transmembrane G protein-coupled receptor superfamily
- alpha1-adrenergic receptor
- protein heterodimerization
Pathways
Biological processes and signaling networks where the ADRA1A gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- bleeding
- infection
- drug dependence
- heroin dependence
- substance-related disorder
- postoperative pain
- pain
- acute pain
- drug abuse
- epithelial cancer
regulated by
- epinastine
- TNFSF11
- norepinephrine
- tetradecanoylphorbol acetate
- phenylephrine
- terazosin
- fluoxetine
- haloperidol
- beta-estradiol
- methoxamine
role in cell
- activation in
- expression in
- apoptosis
- size
- proliferation
- differentiation
- necrosis
- G1/S phase transition
- autophagy by
- signal transduction in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- endoplasmic reticulum/Golgi apparatus fractions
- membrane fraction
- glutaminergic synapse
- intracellular membrane-bounded organelle
- Cytoplasm
- cell surface
- intracellular membranes
- membrane surface
- cellular membrane
- Nucleus
- Endoplasmic Reticulum
- cytosol
- presynaptic membrane
- postsynaptic membrane
- nucleoplasm
- nuclear envelope
- synapse
- Z line
- transverse tubules
- membrane rafts
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ADRA1A gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of synaptic transmission, GABAergic
- positive regulation of protein kinase C signaling cascade
- negative regulation of cell proliferation
- positive regulation of vasoconstriction
- response to xenobiotic stimulus
- pilomotor reflex
- calcium ion transport into cytosol
- positive regulation of smooth muscle contraction
- adult heart development
- MAPK cascade
- negative regulation of heart rate involved in baroreceptor response to increased systemic arterial blood pressure
- smooth muscle contraction
- apoptotic process
- positive regulation of cardiac muscle hypertrophy
- intracellular signal transduction
- positive regulation of cardiac muscle contraction
- G-protein coupled receptor signaling pathway
- signal transduction
- cell-cell signaling
- positive regulation of MAPK cascade
- phospholipase C-activating G-protein coupled receptor signaling pathway
- response to hormone stimulus
- cell growth involved in cardiac muscle cell development
- elevation of cytosolic calcium ion concentration
- norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure
- positive regulation of heart rate by epinephrine-norepinephrine
- positive regulation of action potential
- positive regulation of the force of heart contraction by epinephrine-norepinephrine
- negative regulation of autophagy
- adenylate cyclase-activating adrenergic receptor signaling pathway
- positive regulation of ERK1 and ERK2 cascade
Cellular Component
Where in the cell the gene product is active
- nucleus
- caveola
- nuclear membrane
- cytoplasm
- intracellular membrane-bounded organelle
- cytosol
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- protein heterodimerization activity
- alpha1-adrenergic receptor activity