TRIM6 Gene Summary [Human]
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, B-box type 1 and B-box type 2 domain, and a coiled-coil region. The protein localizes to the nucleus, but its specific function has not been identified. This gene is mapped to chromosome 11p15, where it resides within a TRIM gene cluster. Alternative splicing results in multiple transcript variants. A read-through transcript from this gene into the downstream TRIM34 gene has also been observed, which results in a fusion product from these neighboring family members. [provided by RefSeq, Oct 2010]
Details
| Type | Protein Coding |
| Official Symbol | TRIM6 |
| Official Name | tripartite motif containing 6 [Source:HGNC Symbol;Acc:HGNC:16277] |
| Ensembl ID | ENSG00000121236 |
| Bio databases IDs | |
| Aliases | tripartite motif containing 6 |
| Synonyms | C430046K18RIK, D7Ertd684e, RNF89, Trim22, tripartite motif-containing 6 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TRIM6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- coiled-coil (CC) domain of Drosophila brain tumor (brat) and similar proteins
- protein kinase binding
- B-Box C-terminal domain
- SPRY domain
- zinc finger of C3HC4-type, RING
- ubiquitin protein ligase activity
- protein binding activity, bridging
- transcription factor binding
- enzyme
- Ring finger domain
- protein binding
- identical protein binding
- associated with SPRY domains
- B-box-type zinc finger superfamily
- RING-type zinc-finger
- Ring finger
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- B-box zinc finger
- Outer membrane protein (OmpH-like)
- SPRY-associated domain
- Zinc finger, C3HC4 type (RING finger)
- zinc-RING finger domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TRIM6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein K48-linked ubiquitination
- regulation of protein localization
- protein polyubiquitination
- positive regulation of type I interferon-mediated signaling pathway
- positive regulation of I-kappaB kinase/NF-kappaB cascade
- positive regulation of defense response to virus by host
- positive regulation of NF-kappaB transcription factor activity
- positive regulation of autophagy
- negative regulation of gene expression
- positive regulation of cytokine production involved in immune response
- negative regulation of transcription, DNA-dependent
- regulation of viral entry into host cell
- positive regulation of transcription regulatory region DNA binding
- innate immune response
- negative regulation of stem cell differentiation
- response to lipopolysaccharide
- positive regulation of peptidyl-threonine phosphorylation
- negative regulation of viral genome replication
- free ubiquitin chain polymerization
- positive regulation of peptidyl-serine phosphorylation
- cellular response to interferon-beta
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- zinc ion binding
- identical protein binding
- protein binding
- protein homodimerization activity
- protein binding, bridging