DICER1 Gene Summary [Human]
This gene encodes a protein possessing an RNA helicase motif containing a DEXH box in its amino terminus and an RNA motif in the carboxy terminus. The encoded protein functions as a ribonuclease and is required by the RNA interference and small temporal RNA (stRNA) pathways to produce the active small RNA component that represses gene expression. This protein also acts as a strong antiviral agent with activity against RNA viruses, including the Zika and SARS-CoV-2 viruses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2021]
Details
| Type | Protein Coding |
| Official Symbol | DICER1 |
| Official Name | dicer 1, ribonuclease III [Source:HGNC Symbol;Acc:HGNC:17098] |
| Ensembl ID | ENSG00000100697 |
| Bio databases IDs | |
| Aliases | dicer 1, ribonuclease III, dicer 1, double-stranded RNA-specific endoribonuclease |
| Synonyms | 1110006F08Rik, aviD, D12Ertd7e, DCR1, Dicer, Dicer1e, dicer 1 ribonuclease III, dicer 1, ribonuclease III, dicer 1, ribonuclease type III, GLOW, HELICASE MOI, HERNA, K12H4.8, K12H4.8-LIKE, KIAA0928, mKIAA0928, MNG1, RMSE2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human DICER1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Dicer dimerization domain
- double-stranded RNA binding motif (DSRM) superfamily
- ribonuclease III, bacterial
- DEAD/DEAH box helicase
- protein domain specific binding
- PAZ domain
- enzyme
- protein binding
- 5' phosphomonoester producing endoribonuclease
- RNA binding
- Double-stranded RNA binding motif
- ribonuclease III
- ATPase domain
- Type III restriction enzyme, res subunit
- double-stranded RNA binding
- N-terminal helicase domain of the DEAD-box helicase superfamily
- endoribonuclease
- helicase_insert_domain
- DEAD-like helicases superfamily
- dsRNA-binding domain
- PAZ
- P-loop containing Nucleoside Triphosphate Hydrolases
- RIBOc
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- urogenital cancer
- autoimmune disease
- impaired glucose tolerance
- neoplasia
- obesity
- proteinuria
- fibrosis
- tumorigenesis
- head and neck neoplasia
role in cell
- expression in
- activation in
- migration
- formation
- invasion by
- autophagy in
- cell viability
- cell death
- proliferation
- production in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- glutaminergic synapse
- organelle
- perinuclear region
- Nucleus
- Mitochondria
- ER-to-Golgi intermediate compartment
- cytosol
- Golgi membrane
- sister chromatids
- growth cone
- rough endoplasmic reticulum membrane
- axons
- dendrites
- exosomes
- cytoplasmic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human DICER1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- peripheral nervous system myelin formation
- pre-miRNA processing
- production of miRNAs involved in gene silencing by miRNA
- neuron projection morphogenesis
- positive regulation of Schwann cell differentiation
- nerve development
- negative regulation of transcription from RNA polymerase II promoter
- negative regulation of gene expression
- negative regulation of Schwann cell proliferation
- apoptotic DNA fragmentation
- negative regulation of tumor necrosis factor-mediated signaling pathway
- tRNA catabolic process
- production of siRNA involved in RNA interference
- small RNA loading onto RISC
- negative regulation of tumor necrosis factor production
- positive regulation of myelination
- miRNA metabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular vesicular exosome
- perinuclear region of cytoplasm
- cytoplasm
- RISC-loading complex
- cytosol
- RNA-induced silencing complex
Molecular Function
What the gene product does at the molecular level
- protein domain specific binding
- siRNA binding
- helicase activity
- deoxyribonuclease I activity
- endoribonuclease activity
- DNA binding
- ATP binding
- RNA binding
- ribonuclease III activity
- protein binding
- double-stranded RNA binding
- metal ion binding
- pre-miRNA binding