CEP89 Gene Summary [Human]
Involved in non-motile cilium assembly. Acts upstream of or within cilium assembly. Located in several cellular components, including cytosol; microtubule cytoskeleton; and non-motile cilium. Part of ciliary transition fiber. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Processed Transcript |
| Official Symbol | CEP89 |
| Official Name | centrosomal protein 89 [Source:HGNC Symbol;Acc:HGNC:25907] |
| Ensembl ID | ENSG00000121289 |
| Bio databases IDs | |
| Aliases | centrosomal protein 89 |
| Synonyms | 2610507L03Rik, CCDC123, centrosomal protein 89, CEP123, RGD1311730 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CEP89 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- motile cilia
- ciliary transition fiber
- non-motile cilium
- cilia
- basal bodies
- centrosome
- centriole
- cytosol
- mitochondrial intermembrane space
- nuclear bodies
- spindle pole
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CEP89 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cilium morphogenesis
- synaptic transmission
- mitochondrion organization
Cellular Component
Where in the cell the gene product is active
- mitochondrial intermembrane space
- motile cilium
- centrosome
- centriole
- spindle pole
- cytosol
- synapse
Molecular Function
What the gene product does at the molecular level
- protein binding