ADGRB2 Gene Summary [Human]
This gene encodes a a seven-span transmembrane protein that is thought to be a member of the secretin receptor family. The encoded protein is a brain-specific inhibitor of angiogenesis. The mature peptide may be further cleaved into additional products (PMID:20367554). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]
Details
| Type | Protein Coding |
| Official Symbol | ADGRB2 |
| Official Name | adhesion G protein-coupled receptor B2 [Source:HGNC Symbol;Acc:HGNC:944] |
| Ensembl ID | ENSG00000121753 |
| Bio databases IDs | |
| Aliases | adhesion G protein-coupled receptor B2 |
| Synonyms | adhesion G protein-coupled receptor B2, BAI2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ADGRB2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- Hormone receptor domain
- Thrombospondin type 1 repeats
- Thrombospondin type 1 domain
- 7 transmembrane receptor (Secretin family)
- Adhesion GPCR B N-terminal region
- GPCR proteolysis site, GPS, motif
- protein binding
- Spondin-like TSP1 domain
- seven-transmembrane G protein-coupled receptor superfamily
Pathways
Biological processes and signaling networks where the ADGRB2 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- glutaminergic synapse
- cellular membrane
- synapse
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ADGRB2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- calcineurin-NFAT signaling cascade
- negative regulation of angiogenesis
- G-protein coupled receptor signaling pathway
- peripheral nervous system development
- cell surface receptor signaling pathway
- adenylate cyclase-activating G-protein coupled receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- membrane
- extracellular region
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- G-protein coupled receptor activity
- protein binding