GABPB1 Gene Summary [Human]
This gene encodes the GA-binding protein transcription factor, beta subunit. This protein forms a tetrameric complex with the alpha subunit, and stimulates transcription of target genes. The encoded protein may be involved in activation of cytochrome oxidase expression and nuclear control of mitochondrial function. The crystal structure of a similar protein in mouse has been resolved as a ternary protein complex. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | GABPB1 |
| Official Name | GA binding protein transcription factor subunit beta 1 [Source:HGNC Symbol;Acc:HGNC:4074] |
| Ensembl ID | ENSG00000104064 |
| Bio databases IDs | |
| Aliases | GA binding protein transcription factor subunit beta 1 |
| Synonyms | BABPB2, E4TF1, E4TF1-47, E4TF1-53, E4TF1B, Gabbp2, GA binding protein transcription factor subunit beta 1, GA binding protein transcription factor subunit β 1, Ga-binding protein transcription factor, β subunit 1 (53kd), GABPB, GABPB1-1, GABPB1-2, GABPB-2, GABP beta, GABP beta1, GABP β, Gabp γ, GA repeat binding protein, beta 1, GA repeat binding protein, β 1, Nrf2, Nrf2b, NRF2B1, NRF2B2, RGD1560391 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human GABPB1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- Ankyrin repeats (many copies)
- dimerization domain
- nucleic acid binding
- Ankyrin repeats (3 copies)
- transcription activation domain
- protein binding
- sequence-specific DNA binding
- Ankyrin repeat
- double-stranded DNA binding
- glutamine repeat domain
- Neh6 domain
- Mob-binding domain found in the NDR/LATS family serine/threonine protein kinases
- ankyrin repeats
Pathways
Biological processes and signaling networks where the GABPB1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- neoplasia
- epithelial cancer
- epithelial neoplasia
- osteoarthritis
- head and neck neoplasia
- small cell lung cancer
- tumorigenesis
- kidney injury
- lung carcinoma process
role in cell
- expression in
- proliferation
- activation in
- apoptosis
- migration
- induction in
- organization
- DNA damage response in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- detergent resistant lipid raft fraction
- cytoplasmic ribonucleoprotein granule
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human GABPB1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of transcription from RNA polymerase II promoter
- mitochondrion organization
Cellular Component
Where in the cell the gene product is active
- nucleus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- transcription regulatory region sequence-specific DNA binding