SMU1 Gene Summary [Human]
Involved in mRNA splicing, via spliceosome. Located in nucleus. Part of U2-type precatalytic spliceosome. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | SMU1 |
| Official Name | SMU1 DNA replication regulator and spliceosomal factor [Source:HGNC Symbol;Acc:HGNC:18247] |
| Ensembl ID | ENSG00000122692 |
| Bio databases IDs | |
| Aliases | SMU1 DNA replication regulator and spliceosomal factor, functional spliceosome-associated protein 57 |
| Synonyms | 2600001O03Rik, 2610203K23Rik, BWD, fSAP57, SMU1 DNA replication regulator and spliceosomal factor, SMU1, DNA replication regulator and spliceosomal factor, smu-1 suppressor of mec-8 and unc-52 homolog (C. elegans) |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SMU1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- LisH-like dimerization domain
- WD40 repeats
- WD domain, G-beta repeat
- C-terminal to LisH motif
- WD40
- protein binding
- LisH
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- spliceosomes
- nucleoplasm
- interchromatin granule clusters
- nuclear speckles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SMU1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- RNA splicing
- regulation of alternative nuclear mRNA splicing, via spliceosome
- nuclear mRNA splicing, via spliceosome
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- precatalytic spliceosome
- nuclear speck
- U2-type precatalytic spliceosome
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding