AGO2 Gene Summary [Human]
This gene encodes a member of the Argonaute family of proteins which play a role in RNA interference. The encoded protein is highly basic, and contains a PAZ domain and a PIWI domain. It may interact with dicer1 and play a role in short-interfering-RNA-mediated gene silencing. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
Details
| Type | Protein Coding |
| Official Symbol | AGO2 |
| Official Name | argonaute RISC catalytic component 2 [Source:HGNC Symbol;Acc:HGNC:3263] |
| Ensembl ID | ENSG00000123908 |
| Bio databases IDs | |
| Aliases | argonaute RISC catalytic component 2, argonaute 2 |
| Synonyms | 1110029L17RIK, 2310051F07RIK, AI225898, ARGONAUTE 2, argonaute RISC catalytic component 2, argonaute RISC catalytic subunit 2, CASC7, EIF2C2, Factor 2c2, GERP95, Gm10365, LESKRES, LINC00980, mKIAA4215, PPD, Q10, Su Antigen |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human AGO2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Argonaute linker 2 domain
- Piwi-like
- Hsp70 protein binding
- heat shock protein binding
- Piwi domain
- translation regulator
- RNA 7-methylguanosine cap binding
- double-stranded RNA binding
- ribonucleoprotein binding
- N-terminal domain of argonaute
- RNA cap binding
- nucleic acid binding
- mRNA binding
- enzyme binding
- PAZ domain
- central domain
- protein binding
- 5' phosphomonoester producing endoribonuclease
- sequence-specific DNA binding
- single-stranded RNA binding
- RNA binding
- Mid domain of argonaute
- mRNA 3' UTR binding
- double-stranded DNA binding
- Argonaute linker 1 domain
- endoribonuclease
- PAZ
Pathways
Biological processes and signaling networks where the AGO2 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- heart failure
- lung adenocarcinoma
- lung adenocarcinoma formation
- experimental autoimmune encephalomyelitis
- atopic dermatitis
- anemia
- Lessel-Kreienkamp syndrome
- tumorigenesis
- neurodevelopmental disorder
role in cell
- molecular cleavage in
- binding in
- assembly in
- expression in
- apoptosis
- differentiation
- proliferation
- survival
- accumulation in
- phosphorylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- polyribosome fractions
- GW body
- glutaminergic synapse
- cytoplasmic ribonucleoprotein granule
- cytoplasmic mRNA processing body
- perinuclear region
- postsynaptic region
- microvesicles
- cellular membrane
- Nucleus
- endosomes
- lysosome
- Golgi Apparatus
- Endoplasmic Reticulum
- Mitochondria
- cytoplasmic aggregates
- ER-to-Golgi intermediate compartment
- cytosol
- Golgi membrane
- sister chromatids
- nucleoplasm
- growth cone
- early endosomes
- multivesicular bodies
- stress granule
- rough endoplasmic reticulum membrane
- perikaryon
- axons
- dendrites
- exosomes
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human AGO2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of synapse maturation
- negative regulation of translation involved in gene silencing by miRNA
- negative regulation of translational initiation
- positive regulation of translation
- posttranscriptional gene silencing by RNA
- positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
- pre-miRNA processing
- production of miRNAs involved in gene silencing by miRNA
- post-embryonic development
- positive regulation of nuclear-transcribed mRNA poly(A) tail shortening
- positive regulation of transcription from RNA polymerase II promoter
- translational initiation
- negative regulation of amyloid precursor protein biosynthetic process
- positive regulation of angiogenesis
- translation
- cytoplasmic mRNA processing body assembly
- RNA secondary structure unwinding
- gene silencing by RNA
- small RNA loading onto RISC
- production of siRNA involved in RNA interference
- mRNA cleavage involved in gene silencing by miRNA
- miRNA metabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- dendrite
- extracellular vesicular exosome
- cytoplasm
- membrane
- cytosol
- cytoplasmic mRNA processing body
- RISC-loading complex
- RNA-induced silencing complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- miRNA binding
- siRNA binding
- RNA polymerase II core binding
- endoribonuclease activity
- core promoter sequence-specific DNA binding
- translation initiation factor activity
- RNA 7-methylguanosine cap binding
- RNA binding
- protein binding
- mRNA 3'-UTR AU-rich region binding
- endoribonuclease activity, cleaving siRNA-paired mRNA
- double-stranded RNA binding
- metal ion binding
- single-stranded RNA binding