ZSWIM8 Gene Summary [Human]
Enables ubiquitin ligase-substrate adaptor activity. Involved in positive regulation of miRNA catabolic process; proteasome-mediated ubiquitin-dependent protein catabolic process; and protein ubiquitination. Part of Cul3-RING ubiquitin ligase complex. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | ZSWIM8 |
| Official Name | zinc finger SWIM-type containing 8 [Source:HGNC Symbol;Acc:HGNC:23528] |
| Ensembl ID | ENSG00000214655 |
| Bio databases IDs | |
| Aliases | zinc finger SWIM-type containing 8 |
| Synonyms | 2310021P13Rik, 4832404P21Rik, KIAA0913, LOC103689945, LOC196752, mKIAA0913, RGD1309414, zinc finger SWIM-type containing 8, zinc finger, SWIM-type containing 8 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ZSWIM8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding activity, bridging
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- severe acute respiratory syndrome
regulated by
regulates
- mir-154 (includes others)
- mir-15 (includes others)
- proteasome
- mir-335
- mir-503 (includes others)
- mir-329 (includes others)
- mir-450 (includes others)
- mir-485
- mir-322 (includes others)
role in cell
- 5-fluorouracil resistance
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ZSWIM8 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- proteasomal ubiquitin-dependent protein catabolic process
- positive regulation of miRNA catabolic process
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- cytosol
- Cul2-RING ubiquitin ligase complex
- Cul3-RING ubiquitin ligase complex
Molecular Function
What the gene product does at the molecular level
- zinc ion binding