AGO3 Gene Summary [Human]
This gene encodes a member of the Argonaute family of proteins which play a role in RNA interference. The encoded protein is highly basic, contains a PAZ domain and a PIWI domain, and may play a role in short-interfering-RNA-mediated gene silencing. This gene is located on chromosome 1 in a tandem cluster of closely related family members including argonaute 4 and eukaryotic translation initiation factor 2C, 1. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | AGO3 |
| Official Name | argonaute RISC catalytic component 3 [Source:HGNC Symbol;Acc:HGNC:18421] |
| Ensembl ID | ENSG00000126070 |
| Bio databases IDs | |
| Aliases | argonaute RISC catalytic component 3, argonaute 3 |
| Synonyms | argonaute RISC catalytic component 3, argonaute RISC catalytic subunit 3, C130014L07Rik, EIF2C3 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human AGO3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Argonaute linker 2 domain
- Piwi-like
- N-terminal domain of argonaute
- PAZ domain
- protein binding
- 5' phosphomonoester producing endoribonuclease
- single-stranded RNA binding
- Piwi domain
- translation regulator
- RNA binding
- Mid domain of argonaute
- Argonaute linker 1 domain
- double-stranded RNA binding
- endoribonuclease
- PAZ
Pathways
Biological processes and signaling networks where the AGO3 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- infection by HIV-1
- Barrett syndrome
role in cell
- apoptosis
- growth
- expression in
- proliferation
- differentiation
- RNA post-transciptional gene silencing in
- repression in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- GW body
- cytoplasmic ribonucleoprotein granule
- cytosol
- chromosome
- sister chromatids
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human AGO3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of translation involved in gene silencing by miRNA
- posttranscriptional gene silencing by RNA
- pre-miRNA processing
- production of miRNAs involved in gene silencing by miRNA
- positive regulation of gene expression
- RNA secondary structure unwinding
- regulation of stem cell proliferation
- small RNA loading onto RISC
- mRNA cleavage involved in gene silencing by miRNA
- mRNA catabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- membrane
- RISC-loading complex
- cytosol
- cytoplasmic mRNA processing body
- RNA-induced silencing complex
- condensed nuclear chromosome
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- miRNA binding
- RNA binding
- protein binding
- double-stranded RNA binding
- metal ion binding
- single-stranded RNA binding
- endoribonuclease activity