PAIP2B Gene Summary [Human]
Most mRNAs, except for histones, contain a 3-prime poly(A) tail. Poly(A)-binding protein (PABP; see MIM 604679) enhances translation by circularizing mRNA through its interaction with the translation initiation factor EIF4G1 (MIM 600495) and the poly(A) tail. Various PABP-binding proteins regulate PABP activity, including PAIP1 (MIM 605184), a translational stimulator, and PAIP2A (MIM 605604) and PAIP2B, translational inhibitors (Derry et al., 2006 [PubMed 17381337]).[supplied by OMIM, Mar 2008]
Details
| Type | Protein Coding |
| Official Symbol | PAIP2B |
| Official Name | poly(A) binding protein interacting protein 2B [Source:HGNC Symbol;Acc:HGNC:29200] |
| Ensembl ID | ENSG00000124374 |
| Bio databases IDs | |
| Aliases | poly(A) binding protein interacting protein 2B |
| Synonyms | poly(A) binding protein interacting protein 2B, RGD1307930 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PAIP2B often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ataxin-2 C-terminal region
- nucleic acid binding translation repressor
- poly(A) binding protein
- protein binding
- translation regulator
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Unknown
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PAIP2B gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of translational initiation
- negative regulation of translation
Cellular Component
Where in the cell the gene product is active
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- translation repressor activity
- translation repressor activity, nucleic acid binding