CASC3 Gene Summary [Human]
The product of this gene is a core component of the exon junction complex (EJC), a protein complex that is deposited on spliced mRNAs at exon-exon junctions and functions in nonsense-mediated mRNA decay (NMD). The encoded protein binds RNA and interacts with two other EJC core components. It is predominantly located in the cytoplasm, but shuttles into the nucleus where it localizes to nuclear speckles. [provided by RefSeq, Jul 2008]
Details
| Type | Retained Intron |
| Official Symbol | CASC3 |
| Official Name | CASC3 exon junction complex subunit [Source:HGNC Symbol;Acc:HGNC:17040] |
| Ensembl ID | ENSG00000108349 |
| Bio databases IDs | |
| Aliases | CASC3 exon junction complex subunit |
| Synonyms | Barentsz, BTZ, CASC3 exon junction complex subunit, exon junction complex subunit, MLN 51 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CASC3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SELOR module
- ubiquitin protein ligase binding
- CASC3/Barentsz eIF4AIII binding
- enzyme binding
- coiled-coil domain
- protein binding
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- perinuclear region
- cytosol
- spliceosomes
- nucleoplasm
- nuclear envelope
- perikaryon
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CASC3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mRNA export from nucleus
- regulation of translation
- intracellular mRNA localization
- nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
- regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
- nuclear mRNA splicing, via spliceosome
Cellular Component
Where in the cell the gene product is active
- nucleus
- dendrite
- nuclear membrane
- exon-exon junction complex
- perinuclear region of cytoplasm
- cytoplasmic stress granule
- nuclear speck
- U2-type catalytic step 1 spliceosome
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- RNA binding
- protein binding
- ubiquitin protein ligase binding
- mRNA binding
- enzyme binding