DND1 Gene Summary [Human]
This gene encodes a protein that binds to microRNA-targeting sequences of mRNAs, inhibiting microRNA-mediated repression. Reduced expression of this gene has been implicated in tongue squamous cell carcinoma. Two pseudogenes of this gene are located on the long arm of chromosome 17. [provided by RefSeq, Dec 2010]
Details
| Type | Protein Coding |
| Official Symbol | DND1 |
| Official Name | DND microRNA-mediated repression inhibitor 1 [Source:HGNC Symbol;Acc:HGNC:23799] |
| Ensembl ID | ENSG00000256453 |
| Bio databases IDs | |
| Aliases | DND microRNA-mediated repression inhibitor 1 |
| Synonyms | DND microRNA-mediated repression inhibitor 1, LOC683023, RBMS4, Ter |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human DND1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA recognition motif (RRM) superfamily
- mRNA 3' UTR binding
- RNA recognition motif
- mRNA binding
- double-stranded RNA binding motif (DSRM) superfamily
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- focal adhesions
- Nucleus
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human DND1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- germ cell development
- 3'-UTR-mediated mRNA destabilization
- spermatogenesis
- mRNA stabilization
- negative regulation of gene silencing by miRNA
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- miRNA binding
- protein binding
- mRNA binding
- mRNA 3'-UTR binding