GOT2 Gene Summary [Human]
Glutamic-oxaloacetic transaminase is a pyridoxal phosphate-dependent enzyme which exists in cytoplasmic and inner-membrane mitochondrial forms, GOT1 and GOT2, respectively. GOT plays a role in amino acid metabolism and the urea and tricarboxylic acid cycles. The two enzymes are homodimeric and show close homology. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2013]
Details
| Type | Protein Coding |
| Official Symbol | GOT2 |
| Official Name | glutamic-oxaloacetic transaminase 2 [Source:HGNC Symbol;Acc:HGNC:4433] |
| Ensembl ID | ENSG00000125166 |
| Bio databases IDs | |
| Aliases | glutamic-oxaloacetic transaminase 2, kynurenine aminotransferase IV, aspartate aminotransferase 2, aspartate transaminase 2 |
| Synonyms | AATM, ASPATA, CAT, DEE82, FABPPM, glutamatic-oxaloacetic transaminase 2, mitochondrial, glutamic-oxaloacetic transaminase 2, KAT4, KATIV, KYAT4, mAAT, mAspAT, mitAAT |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human GOT2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- phospholipid binding
- pyridoxal phosphate binding
- binding protein
- aspartate transaminase
- enzyme binding
- AAT_I
- enzyme
- Aminotransferase class I and II
- identical protein binding
- amino acid binding
Pathways
Biological processes and signaling networks where the GOT2 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- epithelial cancer
- obesity
- organismal death
- early infantile epileptic encephalopathy type 82
- psoriasis
- primary central nervous system lymphoma
- primary cancer
- lymphomagenesis
- central nervous system cancer
role in cell
- proliferation
- apoptosis
- phosphorylation in
- influx in
- migration
- invasion by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- plasma membrane fraction
- cell surface
- cellular membrane
- Plasma Membrane
- Mitochondria
- mitochondrial membrane
- mitochondrial matrix
- mitochondrial inner membrane
- sarcolemma
- transverse tubules
- microsomal membrane
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human GOT2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- aspartate metabolic process
- L-kynurenine metabolic process
- 2-oxoglutarate metabolic process
- aspartate biosynthetic process
- aspartate catabolic process
- response to ethanol
- 4-hydroxyproline catabolic process
- glutamate metabolic process
- oxaloacetate metabolic process
- fatty acid transport
- glutamate catabolic process to 2-oxoglutarate
- glutamate catabolic process to aspartate
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- mitochondrial matrix
- mitochondrion
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- pyridoxal phosphate binding
- RNA binding
- L-aspartate:2-oxoglutarate aminotransferase activity
- kynurenine-oxoglutarate transaminase activity