ATP5F1B Gene Summary [Human]
This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3. The proton channel consists of three main subunits (a, b, c). This gene encodes the beta subunit of the catalytic core. [provided by RefSeq, Jul 2008]
Details
| Type | Processed Transcript |
| Official Symbol | ATP5F1B |
| Official Name | ATP synthase F1 subunit beta [Source:HGNC Symbol;Acc:HGNC:830] |
| Ensembl ID | ENSG00000110955 |
| Bio databases IDs | |
| Aliases | ATP synthase F1 subunit beta |
| Synonyms | ATP5B, ATP5beta, ATP5β, ATPB, Atpd, ATPMB, ATPSB, ATP Synthase Beta, ATP Synthase F1 Beta, ATP synthase F1 subunit beta, ATP synthase F1 subunit β, ATP Synthase F1 β, ATP Synthase β, Beta atp synthase, F1 ATPase beta, F1 ATPase β, F1 Atp Synthase β, F1 β atpase, F-type ATPase b, H+ ATP Synthase Beta, H+ ATP Synthase β, HEL-S-271, HUMOP2, Mitochondrial ATP synthase beta subunit, Mitochondrial ATP synthase β subunit, OXPHOS COMPLEX V, subunit B, β atp synthase, β subunit ATP synthase |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ATP5F1B often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- MHC class I protein binding
- adenosine-tetraphosphatase
- ADP binding
- ATP-synt_F1_V1_A1_AB_FliI_N
- ATP synthase alpha/beta family, nucleotide-binding domain
- ATP binding
- H+-transporting two-sector ATPase
- calcium ion binding
- lipoprotein receptor
- hydrogen-transporting ATPase activity, rotational mechanism
- protein binding
- hydrogen-transporting ATP synthase activity, rotational mechanism
- alternate F1F0 ATPase, F1 subunit beta
- ATPase
- ATP synthase alpha/beta family, beta-barrel domain
- proton translocating ATP synthase, F1 alpha subunit
- ATP-synt_F1_V1_A1_AB_FliI_C
- ATP synthase, F1 beta subunit
- P-loop containing Nucleoside Triphosphate Hydrolases
- transporter
- V-type (H+)-ATPase V1, B subunit
Pathways
Biological processes and signaling networks where the ATP5F1B gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- survival
- Huntington disease
- hypermetabolism due to uncoupled mitochondrial oxidative phosphorylation 2
- infection by Bovine rotavirus
- infection by Rotavirus A
- infection by human rotavirus
- infection by Rhesus rotavirus
- infection by Murine rotavirus
- infection by Rotavirus C
- productive infection by HIV-1
role in cell
- growth
- binding in
- migration
- morphology
- Gap 0-Gap 1 phase
- mitochondrial respiration
- glycolysis in
- survival
- alternative splicing in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- myelin enriched fraction
- mitochondrial fraction
- detergent resistant lipid raft fraction
- cristae-like membrane
- cell surface
- cellular membrane
- Plasma Membrane
- Mitochondria
- lipid droplets
- basolateral membrane
- Golgi membrane
- mitochondrial membrane
- mitochondrial matrix
- mitochondrial nucleoids
- mitochondrial inner membrane
- inner nuclear membrane
- nucleoli
- nuclear scaffolds
- membrane rafts
- phagosomes
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ATP5F1B gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of intracellular pH
- generation of precursor metabolites and energy
- negative regulation of cell adhesion involved in substrate-bound cell migration
- angiogenesis
- lipid metabolic process
- osteoblast differentiation
- ATP biosynthetic process
- positive regulation of blood vessel endothelial cell migration
- ATP synthesis coupled proton transport
- mitochondrial ATP synthesis coupled proton transport
Cellular Component
Where in the cell the gene product is active
- proton-transporting ATP synthase complex
- mitochondrial proton-transporting ATP synthase, catalytic core
- plasma membrane
- mitochondrial inner membrane
- mitochondrial nucleoid
- cell surface
- mitochondrial proton-transporting ATP synthase complex
- proton-transporting ATP synthase complex, catalytic core F(1)
- nucleus
- mitochondrial membrane
- extracellular vesicular exosome
- mitochondrial matrix
- mitochondrion
- membrane
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- ATP binding
- protein binding
- MHC class I protein binding
- proton-transporting ATPase activity, rotational mechanism
- angiostatin binding
- hydrogen ion transporting ATP synthase activity, rotational mechanism