RORC Gene Summary [Human]
The protein encoded by this gene is a DNA-binding transcription factor and is a member of the NR1 subfamily of nuclear hormone receptors. The specific functions of this protein are not known; however, studies of a similar gene in mice have shown that this gene may be essential for lymphoid organogenesis and may play an important regulatory role in thymopoiesis. In addition, studies in mice suggest that the protein encoded by this gene may inhibit the expression of Fas ligand and IL2. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | RORC |
| Official Name | RAR related orphan receptor C [Source:HGNC Symbol;Acc:HGNC:10260] |
| Ensembl ID | ENSG00000143365 |
| Bio databases IDs | |
| Aliases | RAR related orphan receptor C |
| Synonyms | IMD42, NR1F3, RAR-related orphan receptor C, RAR-related orphan receptor gamma, RAR-related orphan receptor γ, RORC2, RORG, ROR gamma, RORgammat, ROR γ, RZRG, RZR-GAMMA, RZR-γ, Thor, TOR |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human RORC often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- oxysterol binding
- transcription regulator
- DNA binding domain
- nucleic acid binding
- DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers
- transcription factor binding
- AF-2 transcription activation domain
- transcription modulation domain
- protein binding
- sequence-specific DNA binding
- nuclear receptor ligand binding domain
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional repressor activity
- double-stranded DNA binding
- ligand-binding domain
- ligand-dependent nuclear receptor
- Ligand-binding domain of nuclear hormone receptor
- transcription factor activity
Pathways
Biological processes and signaling networks where the RORC gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- epithelial neoplasia
- neoplasia
- cancer
- liver cancer
- digestive system cancer
- abdominal cancer
- epithelial cancer
- uterine leiomyoma
- insomnia
role in cell
- expression in
- proliferation
- cellular infiltration by
- apoptosis
- number
- quantity
- accumulation
- migration
- upregulation in
- binding in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- intracellular space
- plasma membrane extracellular face
- nucleoplasm
- nuclear bodies
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human RORC gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of fat cell differentiation
- positive regulation of circadian rhythm
- adipose tissue development
- regulation of transcription from RNA polymerase II promoter
- negative regulation of transcription from RNA polymerase II promoter
- circadian regulation of gene expression
- regulation of glucose metabolic process
- positive regulation of transcription, DNA-dependent
- xenobiotic metabolic process
- T-helper 17 cell differentiation
- regulation of steroid metabolic process
- intracellular receptor mediated signaling pathway
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear body
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- sequence-specific DNA binding transcription factor activity
- zinc ion binding
- protein binding
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
- oxysterol binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity