CSF1
CSF1 Gene Summary
The protein encoded by this gene is a cytokine that controls the production, differentiation, and function of macrophages. The active form of the protein is found extracellularly as a disulfide-linked homodimer, and is thought to be produced by proteolytic cleavage of membrane-bound precursors. The encoded protein may be involved in development of the placenta. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011]
Details
| Type | Protein Coding |
| Official Symbol | CSF1 |
| Official Name | colony stimulating factor 1 [Source:HGNC Symbol;Acc:HGNC:2432] |
| Ensembl ID | ENSG00000184371 |
| Bio databases IDs | |
| Aliases | colony stimulating factor 1, macrophage colony stimulating factor 1 |
| Synonyms | BAP025,colony stimulating factor 1,colony stimulating factor 1 (macrophage),CSF1 isoform 1,Csfm,M-CSF,MCSF1,Mhdabap25,op,PG-M-CSF |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Macrophage colony stimulating factor-1 (CSF-1)
- macrophage colony stimulating factor receptor binding
- ligand-binding domain
- protein homodimerization
- protein binding
- cytokine
- identical protein binding
- growth factor
Pathways
Biological processes and signaling networks where the CSF1 gene plays a role, providing insight into its function and relevance in health or disease.
- Altered T Cell and B Cell Signaling in Rheumatoid Arthritis
- Atherosclerosis Signaling
- Hematopoiesis from Multipotent Stem Cells
- Hematopoiesis from Pluripotent Stem Cells
- Hepatic Fibrosis / Hepatic Stellate Cell Activation
- Macropinocytosis Signaling
- MSP-RON Signaling Pathway
- Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis
- Role of Osteoblasts, Osteoclasts and Chondrocytes in Rheumatoid Arthritis
- Role of Tissue Factor in Cancer
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- SGTA
- DNMT1
- CSF1R
- NOTCH2NLA/NOTCH2NLB
- NFIC
- Baf (Brg associated factor complex)
- Baf
- MTUS2
- RNA polymerase II
- HLA-B
disease
- Parkinson disease
- metastasis
- epithelial cancer
- epithelial neoplasia
- cancer
- non-insulin-dependent diabetes mellitus
- neoplasia
- osteoporosis
- rheumatoid arthritis
- fibrosis
regulated by
- FGF2
- lipopolysaccharide
- CSF2
- SIRT6
- dexamethasone
- IL1B
- TNF
- F2RL1
- doxorubicin
- CG
regulates
- Ca2+
- CXCL8
- CD86
- ERK1/2
- NFkB (complex)
- Ccl3
- RELA
- JNK
- AKT
- TNF
role in cell
- growth
- survival
- phosphorylation in
- expression in
- morphology
- activity
- apoptosis
- activation in
- quantity
- invasion by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- cell surface
- perinuclear region
- cellular membrane
- Plasma Membrane
- Golgi Apparatus
- Endoplasmic Reticulum
- endoplasmic reticulum lumen
- nuclear bodies
- extracellular matrix
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the CSF1 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- positive regulation of cell proliferation
- positive regulation of Ras protein signal transduction
- mammary duct terminal end bud growth
- branching involved in mammary gland duct morphogenesis
- positive regulation of multicellular organism growth
- monocyte activation
- osteoclast proliferation
- positive regulation of mononuclear cell proliferation
- positive regulation of protein metabolic process
- developmental process involved in reproduction
- inflammatory response
- response to ischemia
- positive regulation of osteoclast differentiation
- positive regulation of macrophage differentiation
- positive regulation of macrophage chemotaxis
- monocyte differentiation
- macrophage differentiation
- macrophage colony-stimulating factor signaling pathway
- transmembrane receptor protein tyrosine kinase signaling pathway
- Ras protein signal transduction
- positive regulation of odontogenesis of dentin-containing tooth
- neutrophil homeostasis
- mammary gland fat development
- positive regulation of monocyte differentiation
- osteoclast differentiation
- positive regulation of cell-matrix adhesion
- homeostasis of number of cells within a tissue
- positive regulation of protein kinase activity
- innate immune response
- positive regulation of gene expression
- regulation of macrophage derived foam cell differentiation
- monocyte homeostasis
- positive regulation of macrophage derived foam cell differentiation
- regulation of ossification
- positive regulation of cell migration
CELLULAR COMPONENT
Where in the cell the gene product is active
- endoplasmic reticulum lumen
- extracellular space
- nuclear body
- perinuclear region of cytoplasm
- membrane
- extracellular region
- plasma membrane
MOLECULAR FUNCTION
What the gene product does at the molecular level
- growth factor activity
- identical protein binding
- protein homodimerization activity
- protein binding
- cytokine activity
- macrophage colony-stimulating factor receptor binding