NECAB3 Gene Summary [Human]
The protein encoded by this gene interacts with the amino-terminal domain of the neuron-specific X11-like protein (X11L), inhibits the association of X11L with amyloid precursor protein through a non-competitive mechanism, and abolishes the suppression of beta-amyloid production by X11L. This protein, together with X11L, may play an important role in the regulatory system of amyloid precursor protein metabolism and beta-amyloid generation. The protein is phosphorylated by NIMA-related expressed kinase 2, and localizes to the Golgi apparatus. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Details
| Type | Processed Transcript |
| Official Symbol | NECAB3 |
| Official Name | N-terminal EF-hand calcium binding protein 3 [Source:HGNC Symbol;Acc:HGNC:15851] |
| Ensembl ID | ENSG00000125967 |
| Bio databases IDs | |
| Aliases | N-terminal EF-hand calcium binding protein 3, EF-hand calcium binding protein 3 |
| Synonyms | 2900010M17Rik, APBA2BP, dJ63M2.4, dJ63M2.5, EFCBP3, NIP1, N-terminal EF-hand calcium binding protein 3, STIP3, SYTIP2, XB51 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human NECAB3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- EF-hand domain
- EF hand
- Antibiotic biosynthesis monooxygenase
- protein binding
- NIPSNAP
- EFh_PI-PLC
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- membrane fraction
- perinuclear region
- Golgi Apparatus
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
- Golgi cisternae
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human NECAB3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein metabolic process
- protein secretion
- regulation of amyloid precursor protein biosynthetic process
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- nucleus
- cytoplasm
- endoplasmic reticulum
- Golgi apparatus
- Golgi cis cisterna
Molecular Function
What the gene product does at the molecular level
- protein binding
- calcium ion binding