Necab3 Gene Summary [Mouse]
Predicted to enable calcium ion binding activity. Predicted to be involved in regulation of amyloid precursor protein biosynthetic process. Located in Golgi cis cisterna and endoplasmic reticulum. Is expressed in nervous system. Orthologous to human NECAB3 (N-terminal EF-hand calcium binding protein 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Necab3 |
| Official Name | N-terminal EF-hand calcium binding protein 3 [Source:MGI Symbol;Acc:MGI:1861721] |
| Ensembl ID | ENSMUSG00000027489 |
| Bio databases IDs | |
| Aliases | N-terminal EF-hand calcium binding protein 3 |
| Synonyms | 2900010M17Rik, APBA2BP, dJ63M2.4, dJ63M2.5, EFCBP3, NIP1, N-terminal EF-hand calcium binding protein 3, STIP3, SYTIP2, XB51 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Necab3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- EF-hand domain
- EF hand
- Antibiotic biosynthesis monooxygenase
- protein binding
- NIPSNAP
- EFh_PI-PLC
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- membrane fraction
- perinuclear region
- Golgi Apparatus
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
- Golgi cisternae
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Necab3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein metabolic process
- protein secretion
- regulation of amyloid precursor protein biosynthetic process
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- nucleus
- cytoplasm
- endoplasmic reticulum
- Golgi apparatus
- Golgi cis cisterna
Molecular Function
What the gene product does at the molecular level
- protein binding
- calcium ion binding