FCN1 Gene Summary [Human]
The ficolin family of proteins are characterized by the presence of a leader peptide, a short N-terminal segment, followed by a collagen-like region, and a C-terminal fibrinogen-like domain. The collagen-like and the fibrinogen-like domains are also found separately in other proteins such as complement protein C1q, C-type lectins known as collectins, and tenascins. However, all these proteins recognize different targets, and are functionally distinct. Ficolin 1 encoded by FCN1 is predominantly expressed in the peripheral blood leukocytes, and has been postulated to function as a plasma protein with elastin-binding activity. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | FCN1 |
| Official Name | ficolin 1 [Source:HGNC Symbol;Acc:HGNC:3623] |
| Ensembl ID | ENSG00000085265 |
| Bio databases IDs | |
| Aliases | ficolin 1 |
| Synonyms | Fcn2, Fcnb, FCNM, ficolin 1, Ficolin b, M-FICOLIN |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human FCN1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- calcium-dependent protein binding
- signaling receptor activity
- binding protein
- G-protein-coupled receptor binding
- antigen binding
- Collagen triple helix repeat (20 copies)
- protein binding
- polysaccharide binding
- identical protein binding
- FReD
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- rheumatoid arthritis
- abdominal aortic aneurysm
- diabetic nephropathy
- androgenic alopecia
- infection by bacteria
role in cell
- phagocytosis
- production in
- infiltration by
- phagocytosis by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- secretory granule lumen
- ficolin-1-rich granule lumen
- Plasma Membrane
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human FCN1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell surface pattern recognition receptor signaling pathway
- protein localization at cell surface
- positive regulation of interleukin-8 production
- G-protein coupled receptor signaling pathway
- negative regulation of viral entry into host cell
- complement activation, lectin pathway
- proteolysis
- recognition of apoptotic cell
Cellular Component
Where in the cell the gene product is active
- extracellular space
- collagen
- external side of plasma membrane
- secretory granule lumen
- extracellular region
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- G-protein coupled receptor binding
- protein binding
- antigen binding
- metal ion binding
- sialic acid binding
- carbohydrate binding
- receptor binding