TSPAN8 Gene Summary [Human]
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins. This gene is expressed in different carcinomas. The use of alternate polyadenylation sites has been found for this gene. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | TSPAN8 |
| Official Name | tetraspanin 8 [Source:HGNC Symbol;Acc:HGNC:11855] |
| Ensembl ID | ENSG00000127324 |
| Bio databases IDs | |
| Aliases | tetraspanin 8 |
| Synonyms | C76990, CO-029, CO-29, E330007O21Rik, tetraspanin 8, TM4SF3 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TSPAN8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- tetraspanin_LEL
- integrin binding
- protein binding
- Tetraspanin family
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colorectal cancer
- COVID-19
- liver cancer
- epithelial cancer
- metastasis
- hepatocellular carcinoma
- organismal death
- amyotrophic lateral sclerosis
- asthma
- stuttering
role in cell
- expression in
- cell movement
- invasion by
- ubiquitination in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cellular membrane
- intercellular junctions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TSPAN8 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- spermatogenesis
- negative regulation of blood coagulation
- regulation of gene expression
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- protein binding
- integrin binding