Tspan8 Gene Summary [Mouse]
Predicted to enable integrin binding activity. Acts upstream of or within regulation of gene expression and spermatogenesis. Located in cell surface. Is expressed in lung. Orthologous to human TSPAN8 (tetraspanin 8). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tspan8 |
| Official Name | tetraspanin 8 [Source:MGI Symbol;Acc:MGI:2384918] |
| Ensembl ID | ENSMUSG00000034127 |
| Bio databases IDs | |
| Aliases | tetraspanin 8 |
| Synonyms | C76990, CO-029, CO-29, E330007O21Rik, tetraspanin 8, TM4SF3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tspan8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- tetraspanin_LEL
- integrin binding
- protein binding
- Tetraspanin family
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colorectal cancer
- COVID-19
- liver cancer
- epithelial cancer
- metastasis
- hepatocellular carcinoma
- organismal death
- amyotrophic lateral sclerosis
- asthma
- stuttering
role in cell
- expression in
- cell movement
- invasion by
- ubiquitination in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cellular membrane
- intercellular junctions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tspan8 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- spermatogenesis
- negative regulation of blood coagulation
- regulation of gene expression
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- protein binding
- integrin binding