RAP2A Gene Summary [Human]
Enables GTPase activity; guanyl ribonucleotide binding activity; and magnesium ion binding activity. Involved in several processes, including actin cytoskeleton reorganization; microvillus assembly; and positive regulation of protein autophosphorylation. Acts upstream of or within establishment of protein localization. Located in plasma membrane and recycling endosome membrane. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | RAP2A |
| Official Name | RAP2A, member of RAS oncogene family [Source:HGNC Symbol;Acc:HGNC:9861] |
| Ensembl ID | ENSG00000125249 |
| Bio databases IDs | |
| Aliases | RAP2A, member of RAS oncogene family |
| Synonyms | 5830461H18RIK, K-REV, RAP2, RAP2A, member of RAS oncogene family, RAS related protein 2a, RbBP-30 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human RAP2A often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- GTP binding domain
- GTP binding domain-switch II region
- Small GTPase of the Ras superfamily (ill-defined subfamily)
- Ras family
- GTPase
- enzyme
- protein binding
- magnesium ion binding
- effector domain
- Ras subfamily of RAS small GTPases
- GTP binding
- small GTP-binding protein domain
- GDP binding
- Rab subfamily of small GTPases
- Ras of Complex, Roc, domain of DAPkinase
- Rho (Ras homology) subfamily of Ras-like small GTPases
- P-loop containing Nucleoside Triphosphate Hydrolases
Pathways
Biological processes and signaling networks where the RAP2A gene in human plays a role, providing insight into its function and relevance in health or disease.
- Agrin Interactions at Neuromuscular Junction
- Angiopoietin Signaling
- Bladder Cancer Signaling
- Chemokine Signaling
- CNTF Signaling
- ERK5 Signaling
- FLT3 Signaling in Hematopoietic Progenitor Cells
- Glucocorticoid Receptor Signaling
- GM-CSF Signaling
- JAK/Stat Signaling
- LPS-stimulated MAPK Signaling
- Neuregulin Signaling
- Neurotrophin/TRK Signaling
- NF-κB Signaling
- Oncostatin M Signaling
- PAK Signaling
- PDGF Signaling
- PEDF Signaling
- PPAR Signaling
- Prolactin Signaling
- Regulation of IL-2 Expression in Activated and Anergic T Lymphocytes
- Role of JAK1 and JAK3 in γc Cytokine Signaling
- TGF-β Signaling
- Thyroid Cancer Signaling
- UVC-Induced MAPK Signaling
- VEGF Family Ligand-Receptor Interactions
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
role in cell
- adhesion
- phosphorylation in
- assembly
- quantity
- morphology
- migration
- organization
- morphogenesis
- cell spreading
- response by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- detergent-insoluble membrane fraction
- membrane fraction
- Cytoplasm
- cell borders
- perinuclear region
- cellular membrane
- Golgi Apparatus
- Endoplasmic Reticulum
- cytosol
- synaptic membrane
- endosomal membrane
- perinuclear space
- synapse
- recycling endosomes
- tight junctions
- apical cell-cell contacts
- central spindle
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human RAP2A gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein localization
- regulation of dendrite morphogenesis
- regulation of JNK cascade
- establishment of protein localization
- positive regulation of protein autophosphorylation
- establishment of epithelial cell apical/basal polarity
- positive regulation of protein phosphorylation
- microvillus assembly
- cellular response to xenobiotic stimulus
- Rap protein signal transduction
- actin cytoskeleton organization
- regulation of synapse assembly
- negative regulation of cell migration
- protein localization in plasma membrane
Cellular Component
Where in the cell the gene product is active
- cytosol
- recycling endosome
- synaptic membrane
- midbody
- recycling endosome membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- magnesium ion binding
- GTP binding
- protein binding
- GTPase activity
- small monomeric GTPase activity
- GDP binding