GFER Gene Summary [Human]
The hepatotrophic factor designated augmenter of liver regeneration (ALR) is thought to be one of the factors responsible for the extraordinary regenerative capacity of mammalian liver. It has also been called hepatic regenerative stimulation substance (HSS). The gene resides on chromosome 16 in the interval containing the locus for polycystic kidney disease (PKD1). The putative gene product is 42% similar to the scERV1 protein of yeast. The yeast scERV1 gene had been found to be essential for oxidative phosphorylation, the maintenance of mitochondrial genomes, and the cell division cycle. The human gene is both the structural and functional homolog of the yeast scERV1 gene. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | GFER |
| Official Name | growth factor, augmenter of liver regeneration [Source:HGNC Symbol;Acc:HGNC:4236] |
| Ensembl ID | ENSG00000127554 |
| Bio databases IDs | |
| Aliases | growth factor, augmenter of liver regeneration, ERV1 homolog (S. cerevisiae), FAD-linked sulfhydryl oxidase ALR, hepatic regenerative stimulation substance |
| Synonyms | ALR, ERV1, growth factor, augmenter of liver regeneration, HEPATOPOIETIN, HERV1, HPO, HPO1, HPO2, HSS, LOC100912596, MMCHD, MPMCD |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human GFER often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- flavin adenine dinucleotide binding
- Erv1 / Alr family
- flavin-linked sulfhydryl oxidase
- protein disulfide oxidoreductase
- enzyme
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- hepatocellular carcinoma
- epithelial neoplasia
- mitochondrial progressive myopathy with congenital cataract, hearing loss, and developmental delay
- mitochondrial disorder
- epithelial cancer
- hepatic steatosis
- hereditary disorder
- liver cancer
- liver neoplasia
role in cell
- apoptosis
- proliferation
- expression in
- quantity
- formation
- growth
- function
- cell survival
- fragmentation in
- fragmentation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cell surface
- Extracellular Space
- Mitochondria
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human GFER gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular response to actinomycin D
- cellular response to lipopolysaccharide
- signal transduction
- liver development
- negative regulation of apoptotic process
- cellular response to toxin
- cellular response to tumor necrosis factor
- positive regulation of DNA biosynthetic process
- negative regulation of natural killer cell mediated cytotoxicity
Cellular Component
Where in the cell the gene product is active
- mitochondrial intermembrane space
- extracellular space
- mitochondrion
- cytosol
Molecular Function
What the gene product does at the molecular level
- growth factor activity
- protein disulfide oxidoreductase activity
- protein binding
- flavin adenine dinucleotide binding
- flavin-linked sulfhydryl oxidase activity