Gfer Gene Summary [Rat]
Enables flavin-dependent sulfhydryl oxidase activity. Involved in several processes, including cellular response to actinomycin D; liver regeneration; and negative regulation of natural killer cell mediated cytotoxicity. Located in extracellular space. Used to study acute kidney failure. Biomarker of acute kidney failure; cryptorchidism; and ureteral obstruction. Human ortholog(s) of this gene implicated in kidney failure and renal fibrosis. Orthologous to human GFER (growth factor, augmenter of liver regeneration). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gfer |
| Official Name | growth factor, augmenter of liver regeneration [Source:RGD Symbol;Acc:61845] |
| Ensembl ID | ENSRNOG00000013370 |
| Bio databases IDs | |
| Aliases | growth factor, augmenter of liver regeneration |
| Synonyms | ALR, ERV1, growth factor, augmenter of liver regeneration, HEPATOPOIETIN, HERV1, HPO, HPO1, HPO2, HSS, LOC100912596, MMCHD, MPMCD |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Gfer often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- flavin adenine dinucleotide binding
- Erv1 / Alr family
- flavin-linked sulfhydryl oxidase
- protein disulfide oxidoreductase
- enzyme
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- hepatocellular carcinoma
- epithelial neoplasia
- mitochondrial progressive myopathy with congenital cataract, hearing loss, and developmental delay
- mitochondrial disorder
- epithelial cancer
- hepatic steatosis
- hereditary disorder
- liver cancer
- liver neoplasia
role in cell
- apoptosis
- proliferation
- expression in
- quantity
- formation
- growth
- function
- cell survival
- fragmentation in
- fragmentation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cell surface
- Extracellular Space
- Mitochondria
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Gfer gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular response to actinomycin D
- cellular response to lipopolysaccharide
- signal transduction
- liver development
- negative regulation of apoptotic process
- cellular response to toxin
- cellular response to tumor necrosis factor
- positive regulation of DNA biosynthetic process
- negative regulation of natural killer cell mediated cytotoxicity
Cellular Component
Where in the cell the gene product is active
- mitochondrial intermembrane space
- extracellular space
- mitochondrion
- cytosol
Molecular Function
What the gene product does at the molecular level
- growth factor activity
- protein disulfide oxidoreductase activity
- protein binding
- flavin adenine dinucleotide binding
- flavin-linked sulfhydryl oxidase activity