BNIPL Gene Summary [Human]
The protein encoded by this gene interacts with several other proteins, such as BCL2, ARHGAP1, MIF and GFER. It may function as a bridge molecule between BCL2 and ARHGAP1/CDC42 in promoting cell death. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]
Details
| Type | Protein Coding |
| Official Symbol | BNIPL |
| Official Name | BCL2 interacting protein like [Source:HGNC Symbol;Acc:HGNC:16976] |
| Ensembl ID | ENSG00000163141 |
| Bio databases IDs | |
| Aliases | BCL2 interacting protein like |
| Synonyms | 1700128A13Rik, BCL2/adenovirus E1B 19kD interacting protein like, BCL2 interacting protein like, BNIPL-1, BNIPL-2, BNIP-S, PP73, PP753 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human BNIPL often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Domain in homologues of a S
- Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2
- BCH domain
- Divergent CRAL/TRIO domain
- CRAL/TRIO domain
- protein binding
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- prostate cancer
- keratocystic odontogenic tumor
- keratocystic odontogenic tumors
- ductal breast carcinoma
- ductal breast cancer
role in cell
- proliferation
- apoptosis
- cell viability
- growth
- migration
- invasion by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human BNIPL gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of cell proliferation
- apoptotic process
- regulation of growth rate
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding