YY1 Gene Summary [Human]
YY1 is a ubiquitously distributed transcription factor belonging to the GLI-Kruppel class of zinc finger proteins. The protein is involved in repressing and activating a diverse number of promoters. YY1 may direct histone deacetylases and histone acetyltransferases to a promoter in order to activate or repress the promoter, thus implicating histone modification in the function of YY1. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | YY1 |
| Official Name | YY1 transcription factor [Source:HGNC Symbol;Acc:HGNC:12856] |
| Ensembl ID | ENSG00000100811 |
| Bio databases IDs | |
| Aliases | YY1 transcription factor, INO80 complex subunit S, Yin and Yang 1 protein |
| Synonyms | DELTA, GADEVS, Histone alpha factor, Histone α factor, INO80S, NF-E1, NMP-1, UCRBP, Yin and yang 1, YING-YANG-1, YIN-YANG-1, YY1 transcription factor, δ |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human YY1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SMAD binding
- transcription regulator
- Gly-Ala repeat
- DNA secondary structure binding
- transcription factor binding
- chromatin binding
- glycine lysine rich domain
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- Zinc-finger double domain
- Zinc finger, C2H2 type
- glycine rich domain
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- lysine rich domain
- DNA binding domain
- nucleic acid binding
- protein binding
- sequence-specific DNA binding
- acidic domain
- DNA binding
- RNA binding
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional repressor activity
- double-stranded DNA binding
- spacer domain
- histidine-rich region
- zinc finger domain
- transcription factor activity
Pathways
Biological processes and signaling networks where the YY1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- Gabriele-de Vries syndrome
- hyperzincemia and hypercalprotectinemia autoinflammatory syndrome
- metastasis
- hereditary disorder
- head and neck squamous cell carcinoma
- head and neck squamous cell cancer
- organismal death
- breast cancer
- anaplastic thyroid carcinoma
role in cell
- phosphorylation in
- apoptosis
- degradation in
- cell death
- maturation
- production in
- activation in
- proliferation
- association
- growth
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- heterochromatin
- Cytoplasm
- cell surface
- nucleoplasm
- nuclear matrix
- centromeres
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human YY1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of cell growth involved in cardiac muscle cell development
- regulation of chromosome organization
- regulation of DNA strand elongation
- regulation of DNA repair
- anterior/posterior pattern specification
- positive regulation of transcription from RNA polymerase II promoter
- RNA localization
- negative regulation of transcription from RNA polymerase II promoter
- chromatin remodeling
- positive regulation of transcription, DNA-dependent
- cellular response to UV
- regulation of cell cycle
- negative regulation of interferon-beta production
- immunoglobulin heavy chain V-D-J recombination
- positive regulation of DNA repair
- B cell differentiation
- spermatogenesis
- double-strand break repair via homologous recombination
- regulation of embryonic development
- telomere maintenance
- regulation of DNA replication
- response to DNA damage stimulus
- regulation of transcription from RNA polymerase II promoter
- negative regulation of gene expression
- camera-type eye morphogenesis
- positive regulation of gene expression
- cellular response to interleukin-1
- response to UV-C
- response to prostaglandin F stimulus
Cellular Component
Where in the cell the gene product is active
- nucleus
- transcription factor complex
- PcG protein complex
- nuclear matrix
- Ino80 complex
- chromatin
- chromatin silencing complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- transcription regulatory region sequence-specific DNA binding
- core promoter proximal region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity involved in negative regulation of transcription
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
- chromatin binding
- four-way junction DNA binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity
- DNA binding
- protein binding
- RNA binding
- SMAD binding
- metal ion binding