WDR24 Gene Summary [Human]
Involved in cellular response to amino acid starvation; positive regulation of TOR signaling; and regulation of autophagy. Located in cytosol and lysosomal membrane. Part of GATOR2 complex. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | WDR24 |
| Official Name | WD repeat domain 24 [Source:HGNC Symbol;Acc:HGNC:20852] |
| Ensembl ID | ENSG00000127580 |
| Bio databases IDs | |
| Aliases | WD repeat domain 24 |
| Synonyms | BC037651, C16ORF21, DKFZp434F054, JFP7, RGD1304803, WD repeat domain 24 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human WDR24 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- WD40 repeats
- RING/Ubox like zinc-binding domain
- ubiquitin protein ligase activity
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- WD domain, G-beta repeat
- enzyme
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- cytosol
- lysosome membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human WDR24 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of macroautophagy
- cellular response to nutrient levels
- cellular response to amino acid starvation
- autophagy
- regulation of autophagy
- protein K6-linked ubiquitination
- positive regulation of TOR signaling cascade
Cellular Component
Where in the cell the gene product is active
- intracellular membrane-bounded organelle
- cytosol
- vacuolar membrane
- lysosomal membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding