APPBP2 Gene Summary [Human]
The protein encoded by this gene interacts with microtubules and is functionally associated with beta-amyloid precursor protein transport and/or processing. The beta-amyloid precursor protein is a cell surface protein with signal-transducing properties, and it is thought to play a role in the pathogenesis of Alzheimer's disease. The encoded protein may be involved in regulating cell death. This gene has been found to be highly expressed in breast cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
Details
| Type | Protein Coding |
| Official Symbol | APPBP2 |
| Official Name | amyloid beta precursor protein binding protein 2 [Source:HGNC Symbol;Acc:HGNC:622] |
| Ensembl ID | ENSG00000062725 |
| Bio databases IDs | |
| Aliases | amyloid beta precursor protein binding protein 2, protein interacting with APP tail 1 |
| Synonyms | 1300003O07Rik, AI465480, amyloid beta precursor protein binding protein 2, amyloid β precursor protein binding protein 2, HS.84084, KIAA0228, PAT1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human APPBP2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- microtubule binding
- LXXLL motif
- protein binding activity, bridging
- protein binding
- tetratricopeptide repeat
- microtubule motor protein
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- membrane fraction
- cytoplasmic vesicle membrane
- Nucleus
- vesicles
- microtubules
- cytosol
- nucleoplasm
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human APPBP2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- proteasomal ubiquitin-dependent protein catabolic process
- intracellular transport
- intracellular protein transport
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasmic vesicle membrane
- cytoplasm
- Cul2-RING ubiquitin ligase complex
- microtubule associated complex
- microtubule
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- microtubule motor activity
- protein binding