CHTF18 Gene Summary [Human]
This gene encodes a protein which is a component of a replication factor C (RFC) complex, which loads proliferating cell nuclear antigen (PCNA) on to DNA during the S phase of cell cycle. The encoded protein may interact with other proteins, including RFC complex 3, to form a clamp loader complex that plays a role in sister chromatid cohesion during metaphase-anaphase transition. [provided by RefSeq, Jan 2016]
Details
| Type | Retained Intron |
| Official Symbol | CHTF18 |
| Official Name | chromosome transmission fidelity factor 18 [Source:HGNC Symbol;Acc:HGNC:18435] |
| Ensembl ID | ENSG00000127586 |
| Bio databases IDs | |
| Aliases | chromosome transmission fidelity factor 18 |
| Synonyms | 6030457M03Rik, C16orf41, C321D2.2, C321D2.3, C321D2.4, CHL12, chromosome transmission fidelity factor 18, CTF18, CTF18, chromosome transmission fidelity factor 18, RUVBL |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CHTF18 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- single-stranded DNA dependent ATP dependent DNA helicase
- helical lid domain of clamp loader-like AAA+ proteins
- DNA clamp loader
- enzyme
- protein binding
- P-loop containing Nucleoside Triphosphate Hydrolases
- AAA domain
- ATPases associated with a variety of cellular activities
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- lung adenocarcinoma
- lung adenocarcinoma formation
- oligozoospermia
role in cell
- apoptosis
- meiosis
- development
- segregation
- cohesion
- cohesion in
- CSN5i-3 sensitivity
- abnormal morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- heterochromatin
- Cytoplasm
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CHTF18 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA replication
- DNA duplex unwinding
- positive regulation of DNA-directed DNA polymerase activity
Cellular Component
Where in the cell the gene product is active
- Ctf18 RFC-like complex
- nucleus
- membrane
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- DNA binding
- ATP binding
- DNA clamp loader activity
- protein binding
- single-stranded DNA-dependent ATP-dependent DNA helicase activity