ALDOB Gene Summary [Human]
Fructose-1,6-bisphosphate aldolase (EC 4.1.2.13) is a tetrameric glycolytic enzyme that catalyzes the reversible conversion of fructose-1,6-bisphosphate to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. Vertebrates have 3 aldolase isozymes which are distinguished by their electrophoretic and catalytic properties. Differences indicate that aldolases A, B, and C are distinct proteins, the products of a family of related 'housekeeping' genes exhibiting developmentally regulated expression of the different isozymes. The developing embryo produces aldolase A, which is produced in even greater amounts in adult muscle where it can be as much as 5% of total cellular protein. In adult liver, kidney and intestine, aldolase A expression is repressed and aldolase B is produced. In brain and other nervous tissue, aldolase A and C are expressed about equally. There is a high degree of homology between aldolase A and C. Defects in ALDOB cause hereditary fructose intolerance. [provided by RefSeq, Dec 2008]
Details
| Type | Protein Coding |
| Official Symbol | ALDOB |
| Official Name | aldolase, fructose-bisphosphate B [Source:HGNC Symbol;Acc:HGNC:417] |
| Ensembl ID | ENSG00000136872 |
| Bio databases IDs | |
| Aliases | aldolase, fructose-bisphosphate B |
| Synonyms | ALDB, ALDO2, aldolase B, fructose-bisphosphate, aldolase, fructose-bisphosphate B, Fructose Bisphosphatase Aldolase B, Fructose bisphosphate aldolase b, LIV10 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ALDOB often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- phospholipid binding
- ATPase binding
- binding protein
- monosaccharide binding
- cytoskeletal protein binding
- TIM-like beta/alpha barrel domains
- Fructose-bisphosphate aldolase class-I
- fructose-bisphosphate aldolase
- enzyme
- protein binding
- fructose-1-phosphate aldolase activity
- identical protein binding
Pathways
Biological processes and signaling networks where the ALDOB gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- diabetes mellitus
- fibrosis
- diabetic nephropathy
- cancer
- epithelial cancer
- liver cancer
- fructose intolerance
- colon epithelial cancer
- chromophobe renal cell carcinoma
role in cell
- formation in
- binding
- glycolysis in
- O-GlcNAcylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear region
- centrosome
- microtubule organizing centers
- cytosol
- smooth endoplasmatic reticulum
- rough endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ALDOB gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- gluconeogenesis
- vacuolar proton-transporting V-type ATPase complex assembly
- positive regulation of ATPase activity
- glycolysis
- fructose metabolic process
- NADH oxidation
- fructose 1,6-bisphosphate metabolic process
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- microtubule organizing center
- centriolar satellite
- cytosol
Molecular Function
What the gene product does at the molecular level
- fructose binding
- identical protein binding
- protein binding
- cytoskeletal protein binding
- fructose-bisphosphate aldolase activity
- ATPase binding
- binding, bridging