ZBTB38 Gene Summary [Human]
The protein encoded by this gene is a zinc finger transcriptional activator that binds methylated DNA. The encoded protein can form homodimers or heterodimers through the zinc finger domains. In mouse, inhibition of this protein has been associated with apoptosis in some cell types. [provided by RefSeq, Jun 2010]
Details
| Type | Protein Coding |
| Official Symbol | ZBTB38 |
| Official Name | zinc finger and BTB domain containing 38 [Source:HGNC Symbol;Acc:HGNC:26636] |
| Ensembl ID | ENSG00000177311 |
| Bio databases IDs | |
| Aliases | zinc finger and BTB domain containing 38, protein phosphatase 1, regulatory subunit 171 |
| Synonyms | A930014K01Rik, CIBZ, PPP1R171, RGD1310136, zinc finger and BTB domain containing 38, ZNF921 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ZBTB38 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Zinc finger, C2H2 type
- transcription regulator
- Broad-Complex, Tramtrack and Bric a brac
- BTB_POZ
- Zinc-finger double domain
- methyl-CpG binding
- protein homodimerization
- BTB/POZ domain
- zinc finger domain
- protein binding
- transcription factor activity
- C2H2-type zinc ribbon
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- asthma
- atopic dermatitis
- allergic rhinitis
- prostatic carcinoma
- prostate cancer
- epithelial cancer
- chronic obstructive pulmonary disease
- Crohn disease
- multiple sclerosis
regulated by
- beta-estradiol
- N6AMT1
regulates
- synthetic promoter
- DNA promoter
- DNA endogenous promoter
- reporter gene
- RNA polymerase II
- DKK1
role in cell
- expression in
- migration
- proliferation
- progression
- DNA damage response
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear foci
- nucleoplasm
- centromeres
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ZBTB38 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription, DNA-dependent
- regulation of transcription, DNA-dependent
- regulation of DNA replication
- response to DNA damage stimulus
- positive regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- blood microparticle
- chromosome
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- sequence-specific DNA binding transcription factor activity
- protein homodimerization activity
- protein binding
- metal ion binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- methyl-CpG binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity