Chtf18 Gene Summary [Mouse]
Predicted to enable DNA binding activity. Predicted to contribute to DNA clamp loader activity and single-stranded DNA helicase activity. Acts upstream of or within germ cell development; meiotic nuclear division; and negative regulation of chromosome segregation. Located in cytoplasm and male germ cell nucleus. Is expressed in several structures, including brain; genitourinary system; gut; immune system; and integumental system. Orthologous to human CHTF18 (chromosome transmission fidelity factor 18). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | Chtf18 |
| Official Name | CTF18, chromosome transmission fidelity factor 18 [Source:MGI Symbol;Acc:MGI:2384887] |
| Ensembl ID | ENSMUSG00000019214 |
| Bio databases IDs | |
| Aliases | CTF18, chromosome transmission fidelity factor 18 |
| Synonyms | 6030457M03Rik, C16orf41, C321D2.2, C321D2.3, C321D2.4, CHL12, chromosome transmission fidelity factor 18, CTF18, CTF18, chromosome transmission fidelity factor 18, RUVBL |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Chtf18 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- single-stranded DNA dependent ATP dependent DNA helicase
- helical lid domain of clamp loader-like AAA+ proteins
- DNA clamp loader
- enzyme
- protein binding
- P-loop containing Nucleoside Triphosphate Hydrolases
- AAA domain
- ATPases associated with a variety of cellular activities
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- lung adenocarcinoma
- lung adenocarcinoma formation
- oligozoospermia
role in cell
- apoptosis
- meiosis
- development
- segregation
- cohesion
- cohesion in
- CSN5i-3 sensitivity
- abnormal morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- heterochromatin
- Cytoplasm
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Chtf18 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA replication
- DNA duplex unwinding
- positive regulation of DNA-directed DNA polymerase activity
Cellular Component
Where in the cell the gene product is active
- Ctf18 RFC-like complex
- nucleus
- membrane
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- DNA binding
- ATP binding
- DNA clamp loader activity
- protein binding
- single-stranded DNA-dependent ATP-dependent DNA helicase activity