RFPL3 Gene Summary [Human]
Predicted to enable ubiquitin-protein transferase activity. Predicted to be involved in positive regulation of transcription, DNA-templated. Predicted to be located in cytoplasm. Predicted to be active in chromatin and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | RFPL3 |
| Official Name | ret finger protein like 3 [Source:HGNC Symbol;Acc:HGNC:9980] |
| Ensembl ID | ENSG00000128276 |
| Bio databases IDs | |
| Aliases | ret finger protein like 3 |
| Synonyms | ret finger protein like 3, RNF120 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human RFPL3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SPRY domain
- RING-type zinc-finger
- RFPL defining motif (RDM)
- zinc finger of C3HC4-type, RING
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- Ring finger
- protein binding
- associated with SPRY domains
- SPRY-associated domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Unknown
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human RFPL3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of autophagy
- regulation of viral entry into host cell
- regulation of protein localization
- protein polyubiquitination
- innate immune response
- positive regulation of I-kappaB kinase/NF-kappaB cascade
- positive regulation of NF-kappaB transcription factor activity
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- protein homodimerization activity
- protein binding
- metal ion binding