RGP1 Gene Summary [Human]
Enables guanyl-nucleotide exchange factor activity and small GTPase binding activity. Involved in negative regulation of cellular protein catabolic process; positive regulation of GTPase activity; and retrograde transport, endosome to Golgi. Located in cytosol and plasma membrane. Part of Ric1-Rgp1 guanyl-nucleotide exchange factor complex. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | RGP1 |
| Official Name | RGP1 homolog, RAB6A GEF complex partner 1 [Source:HGNC Symbol;Acc:HGNC:21965] |
| Ensembl ID | ENSG00000107185 |
| Bio databases IDs | |
| Aliases | RGP1 homolog, RAB6A GEF complex partner 1 |
| Synonyms | 1110029E03Rik, F730001J03, KIAA0258, mKIAA0258, RAB6A GEF compex partner 1, RGD1311757, RGP1 homolog, RAB6A GEF complex partner 1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human RGP1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- guanyl-nucleotide exchange factor
- enzyme binding
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Plasma Membrane
- cytosol
- trans Golgi network
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human RGP1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of protein catabolic process
- retrograde transport, endosome to Golgi
- positive regulation of GTPase activity
Cellular Component
Where in the cell the gene product is active
- Ric1p-Rgp1p complex
- membrane
- cytosol
- macromolecular complex
- Golgi membrane
- plasma membrane
- trans-Golgi network membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- guanyl-nucleotide exchange factor activity
- small GTPase binding