DNAJB9 Gene Summary [Human]
This gene is a member of the J protein family. J proteins function in many cellular processes by regulating the ATPase activity of 70 kDa heat shock proteins. This gene is a member of the type 2 subgroup of DnaJ proteins. The encoded protein is localized to the endoplasmic reticulum. This protein is induced by endoplasmic reticulum stress and plays a role in protecting stressed cells from apoptosis. [provided by RefSeq, Dec 2010]
Details
| Type | Protein Coding |
| Official Symbol | DNAJB9 |
| Official Name | DnaJ heat shock protein family (Hsp40) member B9 [Source:HGNC Symbol;Acc:HGNC:6968] |
| Ensembl ID | ENSG00000128590 |
| Bio databases IDs | |
| Aliases | DnaJ heat shock protein family (Hsp40) member B9 |
| Synonyms | Dnaj, DnaJ heat shock protein family (Hsp40) member B9, ERdj4, MDG-1, mDj7, MST049, MSTP049 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human DNAJB9 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- DnaJ domain
- DnaJ
- Hsp70 protein binding
- DnaJ molecular chaperone homology domain
- protein binding
- chaperone binding
Pathways
Biological processes and signaling networks where the DNAJB9 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- diabetes mellitus
- preeclampsia
- impaired glucose tolerance
- non-insulin-dependent diabetes mellitus
- hypoinsulinemia
- colon cancer
- hypoglycemia
role in cell
- differentiation
- loss
- endoplasmic reticulum stress response in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- perinuclear region
- cellular membrane
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
- endoplasmic reticulum lumen
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human DNAJB9 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- B cell differentiation
- positive regulation of immunoglobulin production
- response to unfolded protein
- response to endoplasmic reticulum stress
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- endoplasmic reticulum lumen
- extracellular vesicular exosome
- cytoplasm
- endoplasmic reticulum
- nucleolus
Molecular Function
What the gene product does at the molecular level
- protein binding
- chaperone binding
- misfolded protein binding
- Hsp70 protein binding