Dnajb9 Gene Summary [Mouse]
Enables Hsp70 protein binding activity. Involved in B cell differentiation; ERAD pathway; and positive regulation of immunoglobulin production. Located in endoplasmic reticulum lumen. Is expressed in several structures, including alimentary system; integumental system; nervous system; respiratory system; and sensory organ. Orthologous to human DNAJB9 (DnaJ heat shock protein family (Hsp40) member B9). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dnajb9 |
| Official Name | DnaJ heat shock protein family (Hsp40) member B9 [Source:MGI Symbol;Acc:MGI:1351618] |
| Ensembl ID | ENSMUSG00000014905 |
| Bio databases IDs | |
| Aliases | DnaJ heat shock protein family (Hsp40) member B9 |
| Synonyms | Dnaj, DnaJ heat shock protein family (Hsp40) member B9, ERdj4, MDG-1, mDj7, MST049, MSTP049 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Dnajb9 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- DnaJ domain
- DnaJ
- Hsp70 protein binding
- DnaJ molecular chaperone homology domain
- protein binding
- chaperone binding
Pathways
Biological processes and signaling networks where the Dnajb9 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- diabetes mellitus
- preeclampsia
- impaired glucose tolerance
- non-insulin-dependent diabetes mellitus
- hypoinsulinemia
- colon cancer
- hypoglycemia
regulates
- DNAJB9
- glycogen
- insulin
- Immunoglobulin
- Bip
role in cell
- differentiation
- loss
- endoplasmic reticulum stress response in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- perinuclear region
- cellular membrane
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
- endoplasmic reticulum lumen
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Dnajb9 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- B cell differentiation
- positive regulation of immunoglobulin production
- response to unfolded protein
- response to endoplasmic reticulum stress
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- endoplasmic reticulum lumen
- extracellular vesicular exosome
- cytoplasm
- endoplasmic reticulum
- nucleolus
Molecular Function
What the gene product does at the molecular level
- protein binding
- chaperone binding
- misfolded protein binding
- Hsp70 protein binding