CEMIP Gene Summary [Human]
Enables several functions, including clathrin heavy chain binding activity; hyaluronic acid binding activity; and hyalurononglucosaminidase activity. Involved in several processes, including hyaluronan catabolic process; positive regulation of protein phosphorylation; and positive regulation of transport. Located in clathrin-coated endocytic vesicle; endoplasmic reticulum; and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | CEMIP |
| Official Name | cell migration inducing hyaluronidase 1 [Source:HGNC Symbol;Acc:HGNC:29213] |
| Ensembl ID | ENSG00000103888 |
| Bio databases IDs | |
| Aliases | cell migration inducing hyaluronidase 1, hyaluronan-binding protein involved in hyaluronan depolymerization |
| Synonyms | 12H19.01.T7, 6330404C01Rik, 9930013L23Rik, CCSP1, cell migration inducing hyaluronidase 1, cell migration inducing protein, hyaluronan binding, CEMIP1, HYBID, KIAA1199, RGD1305254, TMEM2L |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CEMIP often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G8 domain
- Mucin-2 protein WxxW repeating region
- ER retention sequence binding
- Interleukin-like EMT inducer
- clathrin binding
- enzyme
- protein binding
- hyalurononglucosaminidase
- hyaluronic acid binding
- Domains similar to the Pancreatic-derived factor
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- acute myeloid leukemia
- neoplasia
- breast cancer
- colorectal cancer
- metastatic colorectal cancer
- familial nonsyndromic hearing impairment
- peripheral arterial disease
- dextran sodium sulfate-induced colitis
- lung adenocarcinoma
- lung adenocarcinoma formation
role in cell
- expression in
- proliferation
- phosphorylation in
- apoptosis
- number
- migration
- degradation in
- catabolism in
- O-GlcNAcylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- fibrillar center
- cytoplasmic vesicle membrane
- Extracellular Space
- cellular membrane
- Plasma Membrane
- Endoplasmic Reticulum
- nuclear envelope
- endocytotic vesicle
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CEMIP gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- sensory perception of sound
- positive regulation of protein targeting to membrane
- positive regulation of protein kinase C activity
- positive regulation of peptidyl-threonine phosphorylation
- positive regulation of release of sequestered calcium ion into cytosol
- hyaluronan biosynthetic process
- positive regulation of cell migration
- hyaluronan catabolic process
Cellular Component
Where in the cell the gene product is active
- nuclear membrane
- cytoplasm
- coated pit
- endoplasmic reticulum
- clathrin-coated endocytic vesicle
- extracellular region
- fibrillar center
- plasma membrane
- clathrin coated vesicle membrane
Molecular Function
What the gene product does at the molecular level
- clathrin heavy chain binding
- hyalurononglucosaminidase activity
- protein binding
- hyaluronic acid binding
- carbohydrate binding
- ER retention sequence binding