SIGLEC9 Gene Summary [Human]
Predicted to enable monosaccharide binding activity and sialic acid binding activity. Predicted to be involved in cell adhesion. Predicted to act upstream of or within negative regulation of inflammatory response and negative regulation of phagocytosis, engulfment. Predicted to be located in external side of plasma membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | SIGLEC9 |
| Official Name | sialic acid binding Ig like lectin 9 [Source:HGNC Symbol;Acc:HGNC:10878] |
| Ensembl ID | ENSG00000129450 |
| Bio databases IDs | |
| Aliases | sialic acid binding Ig like lectin 9 |
| Synonyms | CD329, CDw329, FOAP-9, OBBP-LIKE, sialic acid binding Ig like lectin 9 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SIGLEC9 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- immunoreceptor tyrosine-based inhibition motif
- immunoglobulin domain
- ectodomain
- Immunoglobulin like
- sialic acid-binding domain
- protein binding
- membrane-proximal domain
- Immunoglobulin V-set domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
regulated by
- IgG
- TCR (complex)
- pervanadate
- Streptococcus sp group B
- dexamethasone
- SIGLEC9
- FcER1
- filgrastim
- sialic acids
- Pseudomonas aeruginosa
disease
- neoplasia
role in cell
- apoptosis
- expression in
- cell death
- production in
- differentiation
- activation
- number
- binding in
- detachment
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cellular membrane
- secretory granule membrane
- microdomains
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SIGLEC9 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell surface receptor signaling pathway
- cell adhesion
Cellular Component
Where in the cell the gene product is active
- secretory granule membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- sialic acid binding
- carbohydrate binding