LGALS3BP Gene Summary [Human]
The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. LGALS3BP has been found elevated in the serum of patients with cancer and in those infected by the human immunodeficiency virus (HIV). It appears to be implicated in immune response associated with natural killer (NK) and lymphokine-activated killer (LAK) cell cytotoxicity. Using fluorescence in situ hybridization the full length 90K cDNA has been localized to chromosome 17q25. The native protein binds specifically to a human macrophage-associated lectin known as Mac-2 and also binds galectin 1. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | LGALS3BP |
| Official Name | galectin 3 binding protein [Source:HGNC Symbol;Acc:HGNC:6564] |
| Ensembl ID | ENSG00000108679 |
| Bio databases IDs | |
| Aliases | galectin 3 binding protein, L3 antigen, Mac-2-binding protein, serum protein 90K, transport and golgi organization 10 homolog B (Drosophila) |
| Synonyms | 90K, BTBD17B, CyCAP, Gal-3BP, galectin 3 binding protein, gp90, lectin, galactoside-binding, soluble, 3 binding protein, LG3BP, M2BP, MAC-2-BP, mama, PPICAP, TANGO10B |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human LGALS3BP often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Scavenger receptor cysteine-rich domain
- BTB And C-terminal Kelch
- scavenger receptor
- BTB_POZ
- SRCR domain
- protein binding
- BACK (BTB and C-terminal Kelch) domain
- transmembrane receptor
- Scavenger receptor Cys-rich
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Huntington disease
- neoplasia
- metastasis
- epithelial cancer
- COVID-19
- adenocarcinoma
- psoriasis
- organismal death
- cerebral cortical malformation
- systemic lupus erythematosus
role in cell
- expression in
- invasion by
- phosphorylation in
- proliferation
- migration
- apoptosis
- production in
- adhesion
- response
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- extracellular vesicles
- blood microparticle
- secretory granule lumen
- Cytoplasm
- cell surface
- Extracellular Space
- intracellular space
- perinuclear region
- Nucleus
- exosomes
- phagosomes
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human LGALS3BP gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular defense response
- vesicle-mediated transport
- signal transduction
- cell adhesion
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular vesicular exosome
- blood microparticle
- membrane
- platelet dense granule lumen
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein binding
- scavenger receptor activity