NGDN Gene Summary [Human]
Neuroguidin is an EIF4E (MIM 133440)-binding protein that interacts with CPEB (MIM 607342) and functions as a translational regulatory protein during development of the vertebrate nervous system (Jung et al., 2006 [PubMed 16705177]).[supplied by OMIM, Mar 2008]
Details
| Type | Retained Intron |
| Official Symbol | NGDN |
| Official Name | neuroguidin [Source:HGNC Symbol;Acc:HGNC:20271] |
| Ensembl ID | ENSG00000129460 |
| Bio databases IDs | |
| Aliases | neuroguidin |
| Synonyms | 1500001L15Rik, C14orf120, CANu1, LCP5, lpd-2, neuroguidin, neuroguidin, EIF4E binding protein, NGD, RGD1310211 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human NGDN often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Sas10/Utp3/C1D family
- protein binding
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- glutaminergic synapse
- pre-ribosome
- postsynaptic region
- Mitochondria
- nucleoplasm
- nucleoli
- synapse
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human NGDN gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
- ribosomal small subunit biogenesis
Cellular Component
Where in the cell the gene product is active
- small-subunit processome
- dendrite
- mitochondrion
- filopodium
- nucleolus
- chromosome, centromeric region
- axon
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- RNA binding
- protein binding