Ngdn Gene Summary [Mouse]
Predicted to be involved in several processes, including maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); negative regulation of protein localization to plasma membrane; and regulation of translation at postsynapse. Predicted to be located in mitochondrion and nucleoplasm. Predicted to be part of small-subunit processome. Predicted to be active in several cellular components, including glutamatergic synapse; nucleolus; and perforant pathway to dendrate granule cell synapse. Is expressed in 2-cell stage embryo; 4-cell stage embryo; and cerebral cortex ventricular layer. Orthologous to human NGDN (neuroguidin). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ngdn |
| Official Name | neuroguidin, EIF4E binding protein [Source:MGI Symbol;Acc:MGI:1916216] |
| Ensembl ID | ENSMUSG00000022204 |
| Bio databases IDs | |
| Aliases | neuroguidin, EIF4E binding protein |
| Synonyms | 1500001L15Rik, C14orf120, CANu1, LCP5, lpd-2, neuroguidin, neuroguidin, EIF4E binding protein, NGD, RGD1310211 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ngdn often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Sas10/Utp3/C1D family
- protein binding
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- glutaminergic synapse
- pre-ribosome
- postsynaptic region
- Mitochondria
- nucleoplasm
- nucleoli
- synapse
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ngdn gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
- ribosomal small subunit biogenesis
Cellular Component
Where in the cell the gene product is active
- small-subunit processome
- dendrite
- mitochondrion
- filopodium
- nucleolus
- chromosome, centromeric region
- axon
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- RNA binding
- protein binding