SUZ12 Gene Summary [Human]
This zinc finger gene has been identified at the breakpoints of a recurrent chromosomal translocation reported in endometrial stromal sarcoma. Recombination of these breakpoints results in the fusion of this gene and JAZF1. The protein encoded by this gene contains a zinc finger domain in the C terminus of the coding region. [provided by RefSeq, Jul 2009]
Details
| Type | Protein Coding |
| Official Symbol | SUZ12 |
| Official Name | SUZ12 polycomb repressive complex 2 subunit [Source:HGNC Symbol;Acc:HGNC:17101] |
| Ensembl ID | ENSG00000178691 |
| Bio databases IDs | |
| Aliases | SUZ12 polycomb repressive complex 2 subunit |
| Synonyms | 2610028O16Rik, CHET9, D11ERTD530E, IMMAS, JJAZ1, mKIAA0160, SUZ12 polycomb repressive complex 2 subunit |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SUZ12 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- histone binding
- nucleic acid binding
- protein binding activity, bridging
- transcription factor binding
- chromatin binding
- enzyme
- protein binding
- enzyme activator activity
- sequence-specific DNA binding
- DNA binding
- RNA binding
- histone methyltransferase
- double-stranded DNA binding
- VEFS (VRN2-EMF2-FIS2-Su(z)12) box family
- VEFS-Box of polycomb protein
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- cancer
- Imagawa-Matsumoto syndrome
- hereditary disorder
- myelodysplastic/myeloproliferative neoplasm
- myelodysplastic-myeloproliferative disease
- precursor B-cell acute lymphoblastic leukemia
- cervical cancer
- neurofibromatosis 1 associated malignant peripheral nerve sheath tumor
- T acute lymphoblastic leukemia
role in cell
- expression in
- apoptosis
- proliferation
- growth
- differentiation
- invasion
- migration
- invasiveness
- invasion by
- organization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- insoluble fractions
- cytosol
- nucleoplasm
- nucleoli
- nuclear bodies
- sex chromatin
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SUZ12 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- cell proliferation
- oligodendrocyte differentiation
- random inactivation of X chromosome
- negative regulation of cell differentiation
- positive regulation of cell proliferation
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear body
- ESC/E(Z) complex
- sex chromatin
- RSC complex
- nucleolus
- chromatin silencing complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- transcription corepressor binding
- chromatin DNA binding
- protein binding
- metal ion binding
- methylated histone residue binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- histone methyltransferase activity
- enzyme activator activity