DGCR8 Gene Summary [Human]
This gene encodes a subunit of the microprocessor complex which mediates the biogenesis of microRNAs from the primary microRNA transcript. The encoded protein is a double-stranded RNA binding protein that functions as the non-catalytic subunit of the microprocessor complex. This protein is required for binding the double-stranded RNA substrate and facilitates cleavage of the RNA by the ribonuclease III protein, Drosha. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010]
Details
| Type | Protein Coding |
| Official Symbol | DGCR8 |
| Official Name | DGCR8 microprocessor complex subunit [Source:HGNC Symbol;Acc:HGNC:2847] |
| Ensembl ID | ENSG00000128191 |
| Bio databases IDs | |
| Aliases | DGCR8 microprocessor complex subunit |
| Synonyms | C22ORF12, D16H22S1742E, D16H22S788E, D16Wis2, DGCR8 microprocessor complex subunit, DGCR8, microprocessor complex subunit, DGCRK6, Gy1, mir-1306, N41, Pasha, Vo59c07 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human DGCR8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Domain with 2 conserved Trp (W) residues
- Double-stranded RNA binding motif
- double-stranded RNA binding motif (DSRM) superfamily
- double-stranded RNA binding
- WW
- protein binding activity, bridging
- protein homodimerization
- protein binding
- heme binding
- identical protein binding
- WW domain
- RNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- dilated cardiomyopathy
- lung adenocarcinoma
- lung adenocarcinoma formation
- tumorigenesis
- Wilms tumor
- Wilms tumorigenesis
- prostate cancer
- heart failure
- neoplastic cell transformation
role in cell
- number
- frequency
- migration
- expression in
- growth
- apoptosis
- cell viability
- phosphorylation in
- quantity
- proliferation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- glutaminergic synapse
- Cytoplasm
- cytosol
- nucleoplasm
- nuclear bodies
- postsynaptic density
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human DGCR8 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- primary miRNA processing
- regulation of stem cell proliferation
- positive regulation of pre-miRNA processing
- response to DNA damage stimulus
Cellular Component
Where in the cell the gene product is active
- postsynaptic density
- nucleus
- nuclear body
- site of double-strand break
- cytoplasm
- cytosol
- nucleolus
- microprocessor complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein homodimerization activity
- protein binding
- metal ion binding
- double-stranded RNA binding
- primary miRNA binding
- protein binding, bridging
- heme binding