TTI2 Gene Summary [Human]
This gene encodes a regulator of the DNA damage response. The protein is a component of the Triple T complex (TTT) which also includes telomere length regulation protein and TELO2 interacting protein 1. The TTT complex is involved in cellular resistance to DNA damage stresses and may act as a regulator of phosphoinositide-3-kinase-related protein kinase (PIKK) abundance. [provided by RefSeq, May 2013]
Details
| Type | Processed Transcript |
| Official Symbol | TTI2 |
| Official Name | TELO2 interacting protein 2 [Source:HGNC Symbol;Acc:HGNC:26262] |
| Ensembl ID | ENSG00000129696 |
| Bio databases IDs | |
| Aliases | TELO2 interacting protein 2 |
| Synonyms | C8orf41, MRT39, RGD1310414, TELO2 interacting protein 2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TTI2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Tti2 family
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TTI2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of DNA damage checkpoint
- protein stabilization
Cellular Component
Where in the cell the gene product is active
- nucleus